Yang Y M, Wheeler V R, Mankad V N
Department of Pediatrics, University of South Alabama College of Medicine, Mobile.
Am J Pediatr Hematol Oncol. 1990 Summer;12(2):231-6. doi: 10.1097/00043426-199022000-00021.
Pulmonary lipid accumulation associated with intralipid infusion has been observed in autopsies of premature babies and a few adults. We report a 6-year-old boy with radiographically identifiable bilateral pulmonary nodules while he had Staphylococcus epidermidis sepsis. At the time, the child was receiving intralipid as a part of total parenteral nutritional support and was undergoing chemotherapy and radiotherapy for abdominal rhabdomyosarcoma. Pathological studies of the biopsied nodules revealed lipid deposits and foreign body type granulomatous vasculitis. Possible mechanisms for intralipid nodules in the lungs are discussed. Pulmonary intralipid accumulation can occur antemortem and should be included in the differential diagnosis of pulmonary nodules in patients with malignant tumors who are receiving intralipid infusion.
在早产儿和少数成人的尸检中观察到与静脉输注脂肪乳相关的肺部脂质蓄积。我们报告一名6岁男孩，在患表皮葡萄球菌败血症时，影像学上可识别出双侧肺结节。当时，该患儿正在接受脂肪乳作为全胃肠外营养支持的一部分，并且正在接受腹部横纹肌肉瘤的化疗和放疗。对活检结节的病理研究显示有脂质沉积和异物型肉芽肿性血管炎。文中讨论了肺部脂肪乳结节的可能机制。肺部脂肪乳蓄积可在生前发生，对于接受脂肪乳输注的恶性肿瘤患者，应将其纳入肺结节的鉴别诊断中。
