Department of Dermatology, Sina Hospital, Tabriz, Iran.
Int J Dermatol. 2013 Aug;52(8):999-1004. doi: 10.1111/ijd.12002. Epub 2013 Jun 20.
Nicotinamide and clindamycin gels are two popular topical medications for acne vulgaris. This study aimed to compare efficacy of the topical 4% nicotinamide and 1% clindamycin gels in these patients. In this randomized, double-blind clinical trial, patients with moderate inflammatory facial acne vulgaris were randomly allocated to receive either topical 4% nicotinamide (n = 40) or 1% clindamycin gels (n = 40) twice daily. In each group, they were further categorized in two subgroups with oily and non-oily types of facial skin. The Cook's acne grade was determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased from an average of 5.93 ± 0.83 at baseline to 4.03 ± 1.33 at week 4 and 2.08 ± 1.59 at week 8 in nicotinamide receivers, and from an average of 5.70 ± 0.94 at baseline to 3.85 ± 1.66 at week 4 and 2.03 ± 1.53 at week 8 in the clindamycin group (within-group P < 0.001, between-group P > 0.05). Comparing with each other, nicotinamide and clindamycin gels were significantly more efficacious in oily and non-oily skin types, respectively. No major side effect was encountered by any patient. Skin type is a significant factor in choosing between topical nicotinamide and clindamycin in patients with acne vulgaris.
烟酰胺和克林霉素凝胶是两种常用于治疗寻常痤疮的外用药物。本研究旨在比较这两种药物治疗寻常痤疮的疗效。
在这项随机、双盲临床试验中，将 80 例中重度炎性寻常痤疮患者随机分为两组，分别外用 4%烟酰胺（n=40）和 1%克林霉素凝胶（n=40），每日 2 次。在每组中，根据患者面部皮肤的油性和非油性类型，进一步分为两个亚组。在基线和治疗后第 4 周和第 8 周，使用 Cook 痤疮分级法评估痤疮严重程度。
烟酰胺组患者的痤疮严重程度从基线时的平均 5.93±0.83 降至第 4 周时的 4.03±1.33 和第 8 周时的 2.08±1.59，克林霉素组患者的痤疮严重程度从基线时的平均 5.70±0.94 降至第 4 周时的 3.85±1.66 和第 8 周时的 2.03±1.53。组内比较，两组患者在第 4 周和第 8 周时的痤疮严重程度均明显降低（P<0.001）；组间比较，差异无统计学意义（P>0.05）。与克林霉素凝胶相比，烟酰胺凝胶在油性皮肤和非油性皮肤中的疗效更显著。
所有患者均未出现严重不良反应。皮肤类型是寻常痤疮患者选择外用烟酰胺和克林霉素的重要因素。
