Stettler H, Crowther J M, Brandt M, Boxshall A, Lu B, de Salvo R, Laing S, Hennighausen N, Bielfeldt S, Blenkiron P
Bayer Consumer Care AG Basel Switzerland.
JMC Scientific Consulting Ltd. Surrey UK.
Skin Health Dis. 2021 Mar 21;1(2):e21. doi: 10.1002/ski2.21. eCollection 2021 Jun.
Topical moisturizing products are widely used to alleviate the problems associated with xerotic skin. Their use affects many properties of the stratum corneum (SC) in a complex and interrelated manner. The range of measurement techniques available to the researcher has increased in recent years. However, few studies have looked for correlations between the different techniques for assessing how aspects of xerotic skin change over time as a result of topical moisturizer usage.
A 3-week in vivo study using an oil-in-water based moisturizing product and an untreated site was conducted to determine the clinical significance of and any correlations between a range of different approaches for the measurement of skin lipid content and also skin hydration and visual grading of dry skin.
A range of traditional and more recently developed skin measurement techniques have been used to examine a variety of SC properties in normal and xerotic skin during topical moisturizer usage.
In vivo confocal Raman spectroscopy and analysis of SC lipids from tape strips both showed an increase in SC lipid level and organization after 3 weeks of moisturizer usage on xerotic skin. Hydration, measured both optically and electrically, also increased and skin barrier function improved, with strong correlations between the different measures of dryness being observed.
Strong correlations were observed between the skin measurements for lipid assessment and skin hydration with regard to the assessment of xerotic skin, providing valuable new information for future in vivo clinical research into dry and atopic skin. biophysical assessment, skin barrier, skin hydration, topical moisturizers, Xerosis.
外用保湿产品被广泛用于缓解干性皮肤相关问题。其使用以复杂且相互关联的方式影响角质层（SC）的多种特性。近年来，研究人员可使用的测量技术范围有所增加。然而，很少有研究探寻不同技术之间的相关性，以评估由于使用外用保湿剂，干性皮肤各方面如何随时间变化。
进行了一项为期3周的体内研究，使用水包油型保湿产品并设置未处理部位，以确定一系列不同方法测量皮肤脂质含量、皮肤水合作用以及干性皮肤视觉分级之间的临床意义和相关性。
在使用外用保湿剂期间，使用了一系列传统及最新开发的皮肤测量技术来检测正常皮肤和干性皮肤的各种SC特性。
体内共聚焦拉曼光谱法以及胶带条上SC脂质分析均显示，在干性皮肤上使用保湿剂3周后，SC脂质水平和结构增加。通过光学和电学方法测量的皮肤水合作用也增加，皮肤屏障功能改善，且观察到不同干燥程度测量之间存在强相关性。
在干性皮肤评估方面，观察到脂质评估和皮肤水合作用的皮肤测量之间存在强相关性，为未来干性和特应性皮肤的体内临床研究提供了有价值的新信息。生物物理评估、皮肤屏障、皮肤水合作用、外用保湿剂、皮肤干燥症
