Mirmirani Paradi, Maurer Toby, Cohen Mardge, D'Souza Gypsymber, Karim Roksana, Plankey Michael, Robison Esther, Sharma Anjali, Tien Phyllis C, Hessol Nancy A
Department of Dermatology, The Permanente Medical Group, Vallejo, CA, USA.
Int J Dermatol. 2014 Oct;53(10):e443-8. doi: 10.1111/ijd.12044. Epub 2013 Jun 20.
Normal lipid metabolism and functioning of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) in the sebaceous gland is critical to maintaining a normal hair follicle. Human immunodeficiency virus (HIV) infection affects lipid metabolism; some have hypothesized a link between PPAR-gamma function and lipodystrophy in HIV infection. Our objective was to determine whether lipodystrophy is associated with altered hair characteristics in HIV-infected women from the Women's Interagency HIV Study.
Hair characteristics and scalp inflammation were assessed by an interviewer-administered questionnaire. Central lipohypertrophy and peripheral lipoatrophy were defined by self-report of moderate to severe fat gain in central body sites and fat loss in peripheral body sites, respectively confirmed by clinical examination. Additional covariates considered in the analyses included demographics, behavioral characteristics, medical history, and HIV-related factors.
There were 1037 women with data on all study variables; 76 women reported central lipohypertrophy, while only four women reported lipoatrophy. Women with central lipohypertrophy were more likely to be older, had a self-reported history of injection drug use, statin medication use, diabetes, elevated cholesterol, and have self-reported less hair and shorter eyelashes. After adjustment for age, central lipohypertrophy was associated with shorter eyelashes (OR 2.3; 95% CI 1.4-3.8).
Central lipohypertrophy was not associated with change in scalp hair texture or scalp inflammation in this cohort. Rather, we found an association between central lipohypertrophy and shorter eyelash length. This finding may be explained by an influence of prostaglandin E2 mediators on eyelash follicles.
皮脂腺中正常的脂质代谢以及过氧化物酶体增殖物激活受体γ（PPAR-γ）的功能对于维持正常毛囊至关重要。人类免疫缺陷病毒（HIV）感染会影响脂质代谢；一些人推测PPAR-γ功能与HIV感染中的脂肪代谢障碍之间存在联系。我们的目的是确定在女性机构间HIV研究中，脂肪代谢障碍是否与HIV感染女性的毛发特征改变有关。
通过访员管理的问卷评估毛发特征和头皮炎症。中心性脂肪肥厚和外周性脂肪萎缩分别通过自我报告身体中心部位中度至重度脂肪增加和外周部位脂肪减少来定义，并经临床检查确认。分析中考虑的其他协变量包括人口统计学、行为特征、病史和HIV相关因素。
有1037名女性提供了所有研究变量的数据；76名女性报告有中心性脂肪肥厚，而只有4名女性报告有脂肪萎缩。有中心性脂肪肥厚的女性更可能年龄较大，有自我报告的注射吸毒史、使用他汀类药物史、糖尿病史、胆固醇升高，且自我报告头发较少和睫毛较短。在调整年龄后，中心性脂肪肥厚与睫毛较短相关（比值比2.3；95%置信区间1.4 - 3.8）。
在该队列中，中心性脂肪肥厚与头皮毛发质地变化或头皮炎症无关。相反，我们发现中心性脂肪肥厚与睫毛较短之间存在关联。这一发现可能由前列腺素E2介质对睫毛毛囊的影响来解释。
