Rueda Arenas E, García Corzo J, Franco Ospina L
Servicio de Oncología Pediátrica, Departamento de Pediatría, Universidad Industrial de Santander, Servicio de Oncología Pediátrica Hospital Universitario de Santander, Bucaramanga, Colombia.
An Pediatr (Barc). 2013 Dec;79(6):385-9. doi: 10.1016/j.anpedi.2013.04.030. Epub 2013 Jun 17.
Methotrexate used in the treatment of acute lymphocytic leukemia, can cause neurotoxicity, including a rare presentation with hemiparesis. We describe two teenagers, who during the implementation of the M phase of the protocol, suffered hemiparesis, facial paresis and dysarthria which quickly reversed. Leukemia involvement of the central nervous system and stroke, were ruled out. We briefly review the pathophysiology of methotrexate neurotoxicity, the characteristics of the focal paresis presentation and magnetic resonance image findings.
甲氨蝶呤用于治疗急性淋巴细胞白血病时，可引起神经毒性，包括一种罕见的偏瘫表现。我们描述了两名青少年，他们在方案的M期实施过程中出现了偏瘫、面瘫和构音障碍，但这些症状很快就得到了缓解。中枢神经系统白血病累及和中风均被排除。我们简要回顾了甲氨蝶呤神经毒性的病理生理学、局灶性麻痹表现的特征以及磁共振成像结果。
