胆结石患者血清脂质谱分析

Analysis of serum lipid profile in cholelithiasis patients.

作者信息

Batajoo H, Hazra N K

机构信息

Department of Surgery, Manipal Teaching Hospital, Phulbari, Pokhara, Nepal.

出版信息

J Nepal Health Res Counc. 2013 Jan;11(23):53-5.

PMID:23787527

Abstract

BACKGROUND

Gallstone diseases being common disorder, multiple studies have shown an association between gallstones and abnormal lipids. This study is to compare the serum lipid abnormalities in females who have cholelithiasis with controls.

METHODS

A retrospective study of females who underwent cholecystectomy for gallstone disease was carried out. A total of 133 patients were divided into two age groups ≤ 40 and >40 years. In age group ≤ 40 years, there were 72 cases with no controls, whereas, in >40 years, 61 cases were compared with 67 controls. The serum lipid profile were collected and compared according to the age groups. The groups were compared by using Student's t-test, p<0.05 was considered statistically significant.

RESULTS

In age group >40 years serum LDL of gallstone patients were statistically significantly raised (P<0.05) (95% CI -22.077; -850) compared with controls and serum total cholesterol and triglycerides were not statistically significantly high (P >0.05). Serum HDL and VLDL were lower in gallstone patients but not statistically significant (P >0.05) compared to control group.

CONCLUSIONS

The study showed that serum LDL level was statistically significant in females >40 years of age, whereas other parameters were not statistically significantly different.

摘要

背景

胆结石疾病是一种常见疾病，多项研究表明胆结石与血脂异常之间存在关联。本研究旨在比较患有胆石症的女性与对照组的血脂异常情况。

方法

对因胆结石疾病接受胆囊切除术的女性进行回顾性研究。总共133例患者被分为两个年龄组，≤40岁和>40岁。在≤40岁年龄组中，有72例患者，无对照组；而在>40岁年龄组中，61例患者与67例对照组进行比较。根据年龄组收集并比较血脂谱。采用学生t检验进行组间比较，p<0.05被认为具有统计学意义。

结果

在>40岁年龄组中，与对照组相比，胆结石患者的血清低密度脂蛋白（LDL）在统计学上显著升高（P<0.05）（95%可信区间-22.077；-850），血清总胆固醇和甘油三酯无统计学显著升高（P>0.05）。与对照组相比，胆结石患者的血清高密度脂蛋白（HDL）和极低密度脂蛋白（VLDL）较低，但无统计学显著差异（P>0.05）。