血清脂质水平是胆囊结石的危险因素：中国的一项基于人群的研究。
Serum lipid levels are the risk factors of gallbladder stones: a population-based study in China.
机构信息
Department of General Surgery, Zhongshan Hospital, General Surgery Institute, Fudan University, No. 180 Fenglin Rd, Shanghai, 200032, China.
Meinian Onehealth Healthcare Holding Co., Ltd, Shanghai, 200030, China.
出版信息
Lipids Health Dis. 2020 Mar 19;19(1):50. doi: 10.1186/s12944-019-1184-3.
BACKGROUND
Gallstones are the cause of a majority of biliary tract discomfort. Although many community-based studies have addressed the risk factors for gallstone disease (GSD), little is known about GSD prevalence and risk factors in Chinese populations.
METHODS
From January 2014 to January 2015, participants (N = 2,068,523) were recruited by Meinian Onehealth Healthcare Co., Ltd. They received a physical examination, and GSD was determined by ultrasound.
RESULTS
The prevalence of GSD was 8.1%. Risks of GSD were similar between males and females in all age groups. Risk factors for gallstones include body mass index, waist circumference, waist-to-hip ratio, and physical activity, as well as biological factors such as age, sex, and elevated blood lipid levels. Serum lipid levels of GSD were statistically different from controls in total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (H-DL), low-density lipoprotein cholesterol (LDL), and apolipoprotein B (APOB). Furthermore, TC > 5.00 mmol/L, TG > 1.39 mmol/L, HDL < 1.19 mmol/L, LDL > 3.04 mmol/L, and APOB > 0.97 mmol/L were risk factors for gallstones.
CONCLUSIONS
Serum lipid levels are associated with GSD. TC, TG, LDL, and APOB are risk factors, while HDL is a protective factor.
背景
胆结石是大多数胆道不适的原因。虽然许多基于社区的研究已经探讨了胆囊疾病（GSD）的危险因素，但对于中国人群中 GSD 的患病率和危险因素知之甚少。
方法
从 2014 年 1 月至 2015 年 1 月，美年大健康产业（集团）有限公司招募了 2068523 名参与者。他们接受了体检，通过超声确定 GSD。
结果
GSD 的患病率为 8.1%。在所有年龄段，男性和女性的 GSD 风险相似。胆结石的危险因素包括体重指数、腰围、腰臀比和体力活动，以及年龄、性别和血脂水平升高等生物学因素。GSD 的血清脂质水平在总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（H-DL）、低密度脂蛋白胆固醇（LDL）和载脂蛋白 B（APOB）方面与对照组存在统计学差异。此外，TC>5.00mmol/L、TG>1.39mmol/L、HDL<1.19mmol/L、LDL>3.04mmol/L 和 APOB>0.97mmol/L 是胆结石的危险因素。
结论
血清脂质水平与 GSD 相关。TC、TG、LDL 和 APOB 是危险因素，而 HDL 是保护因素。
Zotero 插件