Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands; Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands.
Adv Healthc Mater. 2014 Jan;3(1):70-8. doi: 10.1002/adhm.201300076. Epub 2013 Jun 21.
Minimally invasive intervention strategies after myocardial infarction use state-of-the-art catheter systems that are able to combine mapping of the infarcted area with precise, local injection of drugs. To this end, catheter delivery of drugs that are not immediately pumped out of the heart is still challenging, and requires a carrier matrix that in the solution state can be injected through a long catheter, and instantaneously gelates at the site of injection. To address this unmet need, a pH-switchable supramolecular hydrogel is developed. The supramolecular hydrogel is switched into a liquid at pH > 8.5, with a viscosity low enough to enable passage through a 1-m long catheter while rapidly forming a hydrogel in contact with tissue. The hydrogel has self-healing properties taking care of adjustment to the injection site. Growth factors are delivered from the hydrogel thereby clearly showing a reduction of infarct scar in a pig myocardial infarction model.
心肌梗死后的微创介入策略使用最先进的导管系统，这些系统能够将梗塞区域的映射与药物的精确局部注射相结合。为此，导管输送不能立即从心脏泵出的药物仍然具有挑战性，需要一种载体基质，在溶液状态下可以通过长导管注射，并且在注射部位瞬间胶凝。为了解决这一未满足的需求，开发了一种 pH 可切换的超分子水凝胶。超分子水凝胶在 pH > 8.5 时转变为液体，其粘度足以低到能够通过 1 米长的导管，同时在与组织接触时迅速形成水凝胶。该水凝胶具有自修复特性，可自行调整注射部位。生长因子从水凝胶中释放出来，从而在猪心肌梗死模型中明显显示出梗死瘢痕的减少。
