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Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction.

作者信息

Xu Qiaxin, Xiao Zeyu, Yang Qianzhi, Yu Tingting, Deng Xiujiao, Chen Nenghua, Huang Yanyu, Wang Lihong, Guo Jun, Wang Jinghao

机构信息

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.

The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou, 510630, China.

出版信息

Mater Today Bio. 2024 Feb 13;25:100978. doi: 10.1016/j.mtbio.2024.100978. eCollection 2024 Apr.


DOI:10.1016/j.mtbio.2024.100978
PMID:38434571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10907859/
Abstract

A life-threatening illness that poses a serious threat to human health is myocardial infarction. It may result in a significant number of myocardial cells dying, dilated left ventricles, dysfunctional heart function, and ultimately cardiac failure. Based on the development of emerging biomaterials and the lack of clinical treatment methods and cardiac donors for myocardial infarction, hydrogels with good compatibility have been gradually applied to the treatment of myocardial infarction. Specifically, based on the three processes of pathophysiology of myocardial infarction, we summarized various types of hydrogels designed for myocardial tissue engineering in recent years, including natural hydrogels, intelligent hydrogels, growth factors, stem cells, and microRNA-loaded hydrogels. In addition, we also describe the heart patch and preparation techniques that promote the repair of MI heart function. Although most of these hydrogels are still in the preclinical research stage and lack of clinical trials, they have great potential for further application in the future. It is expected that this review will improve our knowledge of and offer fresh approaches to treating myocardial infarction.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/4895a4f887ba/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/ec4e20394c67/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/818a5b96c897/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/d7f9e0c0528e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/8deccb2043b3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/60985d4252ef/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/3ae439512511/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/b14821ae2082/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/22490e641bbc/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/4895a4f887ba/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/ec4e20394c67/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/818a5b96c897/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/d7f9e0c0528e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/8deccb2043b3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/60985d4252ef/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/3ae439512511/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/b14821ae2082/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/22490e641bbc/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ace/10907859/4895a4f887ba/gr8.jpg

相似文献

[1]
Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction.

Mater Today Bio. 2024-2-13

[2]
The Role of Hydrogel in Cardiac Repair and Regeneration for Myocardial Infarction: Recent Advances and Future Perspectives.

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[3]
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[4]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Injectable Biopolymer-Based Hydrogels: A Next-Generation Platform for Minimally Invasive Therapeutics.

Gels. 2025-5-23

[2]
Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair.

Bioact Mater. 2025-3-9

[3]
Hydrogels for Cardiac Tissue Regeneration: Current and Future Developments.

Int J Mol Sci. 2025-3-5

[4]
Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment.

Bioengineering (Basel). 2025-2-19

[5]
Hybrid hydrogels containing gradients in gold nanoparticles for localized delivery of mesenchymal stem cells and enhanced nerve tissues remodeling .

Mater Today Bio. 2024-12-18

[6]
Exploring the role of hydrogel scaffolds in cardiac regeneration: emphasis on natural extracellular matrix components.

Nanomedicine (Lond). 2025-4

[7]
Innovative hydrogel-based therapies for ischemia-reperfusion injury: bridging the gap between pathophysiology and treatment.

Mater Today Bio. 2024-10-10

[8]
Injectable Hydrogels in Cardiovascular Tissue Engineering.

Polymers (Basel). 2024-7-1

[9]
Therapeutic potentials of allicin in cardiovascular disease: advances and future directions.

Chin Med. 2024-7-2

本文引用的文献

[1]
Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction.

Cell Commun Signal. 2023-8-14

[2]
Triptolide with hepatotoxicity and nephrotoxicity used in local delivery treatment of myocardial infarction by thermosensitive hydrogel.

J Nanobiotechnology. 2023-7-17

[3]
A Conductive and Adhesive Hydrogel Composed of MXene Nanoflakes as a Paintable Cardiac Patch for Infarcted Heart Repair.

ACS Nano. 2023-7-11

[4]
Modified Graphite Pencil Electrode Based on Graphene Oxide-Modified FeO for Ferrocene-Mediated Electrochemical Detection of Hemoglobin.

ACS Omega. 2023-3-24

[5]
miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives.

Int J Mol Sci. 2023-3-8

[6]
Future of myocardial infarction mortality in Iran: a scenario-based study.

J Health Popul Nutr. 2023-3-16

[7]
Gender disparities in prevalence by diagnostic criteria, treatment and mortality of newly diagnosed acute myocardial infarction in Korean adults.

Sci Rep. 2023-3-13

[8]
Injectable polyaniline nanorods/alginate hydrogel with AAV9-mediated VEGF overexpression for myocardial infarction treatment.

Biomaterials. 2023-5

[9]
A carbon based-screen-printed electrode amplified with two-dimensional reduced graphene/FeO nanocomposite as electroanalytical sensor for monitoring 4-aminophenol in environmental fluids.

Chemosphere. 2023-5

[10]
The Role of Hydrogel in Cardiac Repair and Regeneration for Myocardial Infarction: Recent Advances and Future Perspectives.

Bioengineering (Basel). 2023-1-27

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