Abramson D H, Servodidio C A, McCormick B, Fass D, Zang E
New York Hospital, Cornell University Medical Center, New York.
Br J Ophthalmol. 1990 Jun;74(6):359-62. doi: 10.1136/bjo.74.6.359.
Serial ultrasonic measurements of 82 uveal melanomas treated with brachytherapy plaques (cobalt-60 and iodine-125) and followed up for up to 141 months revealed that no two patients had identical patterns of change. The mean absolute change in tumour height after treatment was 1.8 mm at six months, 5.6 mm at 48 months for large tumours, and 0.9 and 1.9 mm for medium sized tumours. Eighty of the 82 patients fell into one of three patterns of response: 57 patients had a decrease in height after treatment (type D), 13 patients had the same height after treatment (type S), and 10 patients had a progressive increase in height (type I). Life table comparison showed no correlation between survival and location of tumour, sex of patient, size of tumour when treated, or laterality. There was a slight correlation between age and survival. Patients older than 60 died more frequently from metastatic melanoma than those under 60 (p = 0.06). Life table analysis showed a significant correlation between tumour regression type and survival. At 48 months the best cumulative probability of survival was in patients with type D (88% alive) compared with those of type I (34% alive, p = 0.0004).
对82例接受近距离放射治疗板（钴 - 60和碘 - 125）治疗并随访长达141个月的葡萄膜黑色素瘤进行连续超声测量，结果显示没有两名患者有相同的变化模式。治疗后六个月肿瘤高度的平均绝对变化为1.8毫米，48个月时大肿瘤为5.6毫米，中等大小肿瘤为0.9毫米和1.9毫米。82例患者中有80例呈现出三种反应模式之一：57例患者治疗后高度降低（D型），13例患者治疗后高度相同（S型），10例患者高度进行性增加（I型）。生命表比较显示，生存与肿瘤位置、患者性别、治疗时肿瘤大小或单侧性之间无相关性。年龄与生存之间存在轻微相关性。60岁以上的患者死于转移性黑色素瘤的频率高于60岁以下的患者（p = 0.06）。生命表分析显示肿瘤消退类型与生存之间存在显著相关性。在48个月时，D型患者的最佳累积生存概率为88%存活，而I型患者为34%存活（p = 0.0004）。
