Augsburger J J, Gamel J W, Shields J A, Markoe A M, Brady L W
Oncology Service, Wills Eye Hospital, Philadelphia, PA 19107.
Ophthalmology. 1987 Sep;94(9):1173-7. doi: 10.1016/s0161-6420(87)33310-x.
To determine the prognostic value of the regression rate of choroidal melanomas after cobalt-60 plaque radiotherapy, the authors performed a multivariate analysis on 159 patients treated with a cobalt plaque during the interval from 1976 through 1980. Thirty-three of the 159 patients had died as of the survey date; 29 of metastatic melanoma and 4 of other causes. Multivariate Cox proportional hazards modeling identified a two-term regression incorporating maximal basal tumor diameter at treatment and tumor thickness at 12 months posttreatment as the best model (P less than 0.005 for both parameters) for predicting length of tumor-free survival. These results are consistent with the hypothesis that rapid regression of a choroidal melanoma after cobalt-60 plaque radiotherapy is an unfavorable prognostic sign for prolonged metastasis-free survival.
为了确定钴 - 60 敷贴放疗后脉络膜黑色素瘤消退率的预后价值，作者对 1976 年至 1980 年间接受钴敷贴治疗的 159 例患者进行了多因素分析。截至调查日期，159 例患者中有 33 例死亡；29 例死于转移性黑色素瘤，4 例死于其他原因。多因素 Cox 比例风险模型确定，纳入治疗时最大基底肿瘤直径和治疗后 12 个月肿瘤厚度的二元回归是预测无瘤生存期的最佳模型（两个参数的 P 值均小于 0.005）。这些结果与以下假设一致，即钴 - 60 敷贴放疗后脉络膜黑色素瘤的快速消退是无转移生存期延长的不良预后标志。
