Institute of Neuroscience and Medicine (INM-1, INM-4), Research Centre Jülich, Jülich, Germany.
Science. 2013 Jun 21;340(6139):1472-5. doi: 10.1126/science.1235381.
Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.
参考大脑是人类大脑映射中不可或缺的工具，使多模态数据能够整合到一个解剖学上逼真的标准空间中。然而，现有的参考大脑仅限于宏观尺度，无法提供关于功能重要的微观维度的信息。我们基于对 7404 个组织学切片的重建，创建了一个具有近细胞分辨率 20 微米的超高分辨率三维（3D）人脑模型。“BigBrain”是一个免费的、公开可用的工具，它为人类大脑提供了大量的神经解剖学见解，从而可以提取微观数据进行建模和模拟。BigBrain 可以测试关于相互连接的皮质区域之间的最佳路径长度或遗传模式空间组织的假设，从而重新定义了传统的神经解剖学图谱，如 Brodmann 和 von Economo 的图谱。
