Gledo Ibrahim, Pranjic Nurka, Drljević Kenan, Prasko Subhija, Drljevic Irdina, Brzeziński Piotr
Department of Family Medicine, Health Care Centre Zenica, Zenica, Bosnia and Herzegovina.
Contemp Oncol (Pozn). 2012;16(6):551-6. doi: 10.5114/wo.2012.32489. Epub 2013 Jan 4.
Exposure to radiation and aging are the leading causes of breast cancer among female patients. We aimed to investigate and assess the relationship between exposure to medical, diagnostic and iatrogenic radiation and breast cancer using a questionnaire among 100 newly diagnosed female breast cancer patients and 100 control female subjects without cancer.
A case control study using a family ambulatory based survey was conducted among 200 female patients from all municipalities of Zenica-Doboj Canton. New cases of breast cancer among subjects of experimental groups (n = 100) were diagnosed between 1 January 2003 and 31 December 2007 using the institutional clinical procedure for breast cancer diagnosis. Data were obtained using a self-rated questionnaire on radiation as a breast carcinogen. Data analysis was performed using SPSS version 19.0.
There were no significant differences between the two groups and their subgroups for individual data and demographics except for prevalence of decreased family financial situation (practical poverty) among subjects with breast cancer in relation to control subjects (31%: 17% among control subjects; p = 0.001). Female patients who are exposed to iatrogenic radiation before the 3(rd) year of life (OR = 1.29; 95% CI: 0.839-1.985) and those who are exposed to CT more than twice per year are more than twice as likely to have breast carcinoma (OR = 2.02; 95% CI: 1.254-3.261) compared to control subjects. Poverty and low family income are vulnerability factors associated with elevated levels of breast carcinoma. This result is not in accordance with prior study results.
It is necessary to develop an adequate registration system of iatrogenic exposure to radiation for each patient of any age, particularly for children aged < 3 years and for CT iatrogenic exposure.
在女性患者中，接触辐射和衰老是乳腺癌的主要病因。我们旨在通过问卷调查，对100名新确诊的女性乳腺癌患者和100名无癌症的对照女性受试者进行调查和评估，以研究和评估医疗、诊断和医源性辐射暴露与乳腺癌之间的关系。
采用基于家庭门诊的调查进行病例对照研究，研究对象为来自泽尼察 - 多博伊州所有市镇的200名女性患者。实验组（n = 100）的乳腺癌新病例是在2003年1月1日至2007年12月31日期间，使用机构乳腺癌诊断临床程序确诊的。通过一份关于辐射作为乳腺癌致癌物的自评问卷获取数据。使用SPSS 19.0版进行数据分析。
除乳腺癌患者中家庭经济状况下降（实际贫困）的患病率与对照受试者相比存在差异外（31%：对照受试者中为17%；p = 0.001），两组及其亚组在个体数据和人口统计学方面无显著差异。与对照受试者相比，在3岁之前接触医源性辐射的女性患者（OR = 1.29；95% CI：0.839 - 1.985）以及每年接受CT检查超过两次的女性患者患乳腺癌的可能性高出两倍多（OR = 2.02；95% CI：1.254 - 3.261）。贫困和低家庭收入是与乳腺癌水平升高相关的脆弱因素。这一结果与先前的研究结果不一致。
有必要为任何年龄的每位患者，特别是3岁以下儿童和CT医源性辐射暴露患者，建立完善的医源性辐射暴露登记系统。
