Tulek Baykal, Koylu Habibe, Kanat Fikret, Arslan Ugur, Ozer Faruk
Department of Pulmonary Medicine, Selcuklu Faculty of Medicine, Selcuk University, Konya, Turkey.
Contemp Oncol (Pozn). 2013;17(1):68-72. doi: 10.5114/wo.2013.33777. Epub 2013 Mar 15.
The basic uses of C-reactive protein (CRP) and procalcitonin (PCT) in clinical practice are in the diagnosis and follow-up of infectious disease. The fact that CRP already achieves high levels in cases with lung cancer, however, limits its diagnostic specificity. Procalcitonin may be an important marker in the differential diagnosis of lung cancer patients who have fever and high CRP levels. Our objective in this study was to determine the levels of CRP and PCT in patients with newly diagnosed non-infectious non-small cell lung cancer (NSCLC) and to relate these results to patient and disease characteristics.
Serum CRP and PCT levels were measured in 79 histopathologically proven NSCLC patients and 20 healthy controls. Results were compared with demographic and clinical variables in patients with NSCLC.
Serum CRP concentrations were significantly higher in NSCLC patients compared to the control group [38.30 (7.79-185) mg/dl vs. 7.79 (3.36-26.10) mg/dl; p < 0.001]. There was no significant difference between the two groups in PCT levels (p > 0.05). A mild, positive correlation was found between CRP level and tumor diameter. When comparing CRP levels in the lung cancer patients grouped according to age, sex, smoking status, clinical TNM staging and performance status (PS), the only significant difference found was that for PS score.
High serum CRP levels in non-infectious NSCLC patients are mainly related to PS status and weakly to tumor size. Adding serum PCT measurement may contribute to exclusion of infections in patients with NSCLC.
C反应蛋白（CRP）和降钙素原（PCT）在临床实践中的基本用途是用于传染病的诊断和随访。然而，CRP在肺癌患者中已达到高水平这一事实限制了其诊断特异性。降钙素原可能是发热且CRP水平高的肺癌患者鉴别诊断中的一个重要标志物。本研究的目的是测定新诊断的非感染性非小细胞肺癌（NSCLC）患者的CRP和PCT水平，并将这些结果与患者及疾病特征相关联。
对79例经组织病理学证实的NSCLC患者和20名健康对照者测定血清CRP和PCT水平。将结果与NSCLC患者的人口统计学和临床变量进行比较。
与对照组相比，NSCLC患者的血清CRP浓度显著更高[38.30（7.79 - 185）mg/dl对7.79（3.36 - 26.10）mg/dl；p < 0.001]。两组间PCT水平无显著差异（p > 0.05）。发现CRP水平与肿瘤直径之间存在轻度正相关。在根据年龄、性别、吸烟状况、临床TNM分期和体能状态（PS）分组的肺癌患者中比较CRP水平时，发现唯一显著差异在于PS评分。
非感染性NSCLC患者的高血清CRP水平主要与PS状态相关，与肿瘤大小的相关性较弱。增加血清PCT检测可能有助于排除NSCLC患者的感染。
