Guo Yi, Yin Jiangyan, Zha Lang, Wang Ziwei
Department of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Contemp Oncol (Pozn). 2013;17(2):150-5. doi: 10.5114/wo.2013.34618. Epub 2013 Apr 29.
Platelet-derived growth factor B (PDGF-B), a vital growth factor which can induce angiogenesis and epithelial-mesenchymal transition (EMT), is important in the metastasis of many tumors. However, the roles of PDGF-B in gastric carcinoma are largely unknown. We investigated the correlation between PDGF-B, PDGFR-β and E-cadherin expression with the clinical features of gastric carcinoma patients to evaluate the relationship between PDGF-B signaling, E-cadherin and metastasis of gastric carcinoma, the correlation between PDGF-B and E-cadherin expression to assess the roles of PDGF-B signaling in metastasis of gastric carcinoma..
We detected expressions of PDGF-B, PDGFR-β and E-cadherin in gastric carcinoma tissues and normal gastric mucosa tissues of 64 patients with gastric carcinoma who had undergone surgical resection, and investigated their relationships with clinical features and the relationships between PDGF-B and E-cadherin expression in gastric carcinoma.
In surgical specimens, tumor cells expressed PDGF-B, and PDGFR-β was expressed by tumor stromal cells. E-cadherin was expressed by both tumor cells and normal gastric mucosa cells. Expressions of PDGF-B and PDGFR-β were increased in gastric carcinoma tissues (p < 0.05) and were positively correlated with the depth of cancer invasion, lymph node metastasis and TNM stage (p < 0.05). The expression of E-cadherin was reduced in gastric carcinoma tissues (p < 0.05) and was negatively correlated with the depth of cancer invasion, lymph node metastasis and TNM stage (p < 0.05). The correlation between PDGF-B and E-cadherin expression was negative (p < 0.05).
Our data indicate that either the overexpression of PDGF-B and PDGFR-β or the underexpression of E-cadherin is correlated with cancer progression and lymphogenous metastasis of gastric carcinoma. The PDGF-B signal pathway might induce EMT by down-regulating expression of E-cadherin to promote metastasis of gastric carcinoma.
血小板衍生生长因子B（PDGF - B）是一种重要的生长因子，可诱导血管生成和上皮 - 间质转化（EMT），在多种肿瘤的转移中起重要作用。然而，PDGF - B在胃癌中的作用尚不清楚。我们研究了PDGF - B、PDGFR - β和E - 钙黏蛋白表达与胃癌患者临床特征之间的相关性，以评估PDGF - B信号传导、E - 钙黏蛋白与胃癌转移之间的关系，以及PDGF - B与E - 钙黏蛋白表达之间的相关性，以评估PDGF - B信号传导在胃癌转移中的作用。
我们检测了64例行手术切除的胃癌患者的癌组织和正常胃黏膜组织中PDGF - B、PDGFR - β和E - 钙黏蛋白的表达，并研究了它们与临床特征的关系以及胃癌中PDGF - B与E - 钙黏蛋白表达之间的关系。
在手术标本中，肿瘤细胞表达PDGF - B，肿瘤基质细胞表达PDGFR - β。肿瘤细胞和正常胃黏膜细胞均表达E - 钙黏蛋白。PDGF - B和PDGFR - β在胃癌组织中的表达增加（p < 0.05），并与癌浸润深度、淋巴结转移和TNM分期呈正相关（p < 0.05）。E - 钙黏蛋白在胃癌组织中的表达降低（p < 0.05），并与癌浸润深度、淋巴结转移和TNM分期呈负相关（p < 0.05）。PDGF - B与E - 钙黏蛋白表达之间的相关性为负（p < 0.05）。
我们的数据表明，PDGF - B和PDGFR - β的过表达或E - 钙黏蛋白的低表达与胃癌的进展和淋巴转移相关。PDGF - B信号通路可能通过下调E - 钙黏蛋白的表达诱导EMT，从而促进胃癌转移。
