Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, VIC 3052, Australia.
J Clin Neurosci. 2013 Oct;20(10):1448-9. doi: 10.1016/j.jocn.2012.11.009. Epub 2013 Jun 18.
We report a 78-year-old man who presented with rapidly progressive cerebellar ataxia, dysarthria and vertigo. MRI of the brain showed no evidence of infiltrative pathology in the posterior fossa. Cerebrospinal fluid analysis revealed an elevated protein and pleocytosis. He was subsequently diagnosed with squamous cell carcinoma of the lung on bronchoscopy. Paraneoplastic cerebellar degeneration (PCD) was diagnosed. To our knowledge, there are only two previously reported patients with PCD associated with squamous cell carcinoma of the lung.
我们报告了一例 78 岁男性患者,其表现为进行性小脑共济失调、构音障碍和眩晕。脑部 MRI 未见后颅窝浸润性病变的证据。脑脊液分析显示蛋白升高和白细胞增多。随后在支气管镜检查中诊断为肺癌鳞状细胞癌。诊断为副肿瘤性小脑变性(PCD)。据我们所知,以前仅有两例报道的与肺癌相关的 PCD 患者。