RIKILT, Wageningen University and Research Centre, P.O. Box 230, 6700 AE Wageningen, The Netherlands.
Food Chem. 2013 Nov 15;141(2):1489-95. doi: 10.1016/j.foodchem.2013.04.035. Epub 2013 Apr 19.
Dietary intake is the predominant route for human exposure to perfluorooctane sulfonic acid (PFOS). Single pollution events may thus affect human exposure if polluted ground and water is used to produce animal feed or food. In this study, a physiologically based pharmacokinetic (PBPK-) model is derived that describes the uptake of PFOS from contaminated feed by cows and its subsequent elimination through the cows' milk. Parameter values of the model were estimated by fitting to experimental data of a cow feeding trial. Model calculations showed that almost all PFOS ingested is excreted through the cows' milk. The elimination rate, however, was low as the estimated half-life in the cow was 56days and it may, thus, take a long time after an initial pollution event to produce PFOS-free milk. The derived model can be used to estimate the transfer of PFOS through the dairy food chain and can be used for comparison of various contamination routes.
饮食摄入是人类接触全氟辛烷磺酸（PFOS）的主要途径。因此，如果受污染的土壤和水被用于生产动物饲料或食品，单次污染事件可能会影响人类的暴露。在这项研究中，我们推导出了一个基于生理学的药代动力学（PBPK-）模型，该模型描述了奶牛从受污染的饲料中摄取 PFOS 及其随后通过牛奶排出的过程。通过拟合奶牛喂养试验的实验数据来估计模型的参数值。模型计算表明，几乎所有摄入的 PFOS 都通过牛奶排出。然而，由于在奶牛体内的估计半衰期为 56 天，因此消除速度较低，因此在初始污染事件发生后可能需要很长时间才能生产出不含 PFOS 的牛奶。推导出的模型可用于估计 PFOS 通过乳制品食物链的转移，并可用于比较各种污染途径。
