Monteleone P, Gnocchi G
Department of Psychiatry, Mental Health Service U.S.L. 41, Naples, Italy.
Clin Neuropharmacol. 1990;13 Suppl 1:S84-9. doi: 10.1097/00002826-199001001-00010.
To investigate a possible relationship between plasma levels of trazodone and its clinical antidepressant effects, 11 elderly depressed patients underwent a 5-week treatment with 150 mg/day trazodone in three oral administrations. Clinical antidepressant response was assessed with two different clinical improvement criteria and plasma trazodone concentrations were determined by high-performance liquid chromatography. A significant correlation was found between steady-state plasma trazodone levels and its antidepressant efficacy, but not between plasma drug levels and the incidence of side effects. Moreover, the steady-state plasma trazodone concentration of 650 ng/ml was identified as threshold value for a greater occurrence of good antidepressant responses.
为了研究曲唑酮的血浆水平与其临床抗抑郁效果之间的可能关系，11名老年抑郁症患者接受了为期5周的治疗，每天口服150毫克曲唑酮，分三次服用。采用两种不同的临床改善标准评估临床抗抑郁反应，并通过高效液相色谱法测定血浆曲唑酮浓度。发现稳态血浆曲唑酮水平与其抗抑郁疗效之间存在显著相关性，但血浆药物水平与副作用发生率之间无显著相关性。此外，650纳克/毫升的稳态血浆曲唑酮浓度被确定为产生更好抗抑郁反应的阈值。
