Monteleone P, Gnocchi G, Delrio G
Department of Psychiatry, Mental Health Service U.S.L. 41, Naples, Italy.
J Clin Psychopharmacol. 1989 Aug;9(4):284-7.
Steady-state plasma levels of trazodone were determined by HPLC in 11 elderly depressed patients who underwent a 5-week pharmacological treatment with 150 mg/day trazodone in three oral administrations. Clinical antidepressant response, assessed with three different clinical improvement criteria, was significantly correlated with steady-state plasma trazodone concentrations. Moreover, the steady-state plasma trazodone concentration of 650 ng/ml was identified as the threshold value for a good antidepressant response. No correlation was found between the occurrence of side effects and plasma levels of trazodone.
