Division of Rheumatology, Istituto Gaetano Pini, Department of Clinical Sciences & Community Health, University of Milano, Milano, Italy.
Microvasc Res. 2013 Sep;89:122-8. doi: 10.1016/j.mvr.2013.06.003. Epub 2013 Jun 17.
The aims of this study were to obtain cross-sectional data on capillaroscopy in an international multi-center cohort of Systemic Sclerosis (SSc) and to investigate the frequency of the capillaroscopic patterns and their disease-phenotype associations.
Data collected between June 2004 and October 2011 in the EULAR Scleroderma Trials and Research (EUSTAR) registry were examined. Patients' profiles based on clinical and laboratory data were obtained by cluster analysis and the association between profiles and capillaroscopy was investigated by multinomial logistic regression.
62 of the 110 EUSTAR centers entered data on capillaroscopy in the EUSTAR database. 376 of the 2754 patients (13.65%) were classified as scleroderma pattern absent, but non-specific capillary abnormalities were noted in 55.48% of the cases. Four major patients' profiles were identified characterized by a progressive severity for skin involvement, as well as an increased number of systemic manifestations. The "early" and "active" scleroderma patterns were generally observed in patients with mild/moderate skin involvement and a low number of disease manifestations, while the "late" scleroderma pattern was found more frequently in the more severe forms of the disease.
These data indicate the importance of capillaroscopy in SSc management and that capillaroscopic patterns are directly related to the extent of organ involvement.
本研究旨在获得系统性硬化症（SSc）国际多中心队列的毛细血管镜检查的横断面数据，并探讨毛细血管镜模式的频率及其与疾病表型的关系。
检查了 2004 年 6 月至 2011 年 10 月期间在 EULAR 硬皮病试验和研究（EUSTAR）注册中心收集的数据。通过聚类分析获得基于临床和实验室数据的患者特征，并通过多项逻辑回归分析研究特征与毛细血管镜检查之间的关系。
在 EUSTAR 数据库中，110 个 EUSTAR 中心中有 62 个中心输入了毛细血管镜检查数据。在 2754 例患者中，有 376 例（13.65%）被归类为无硬皮病模式，但 55.48%的病例存在非特异性毛细血管异常。确定了四个主要的患者特征，其特征为皮肤受累的严重程度逐渐增加，以及全身表现的数量增加。“早期”和“活跃”的硬皮病模式通常见于皮肤受累程度较轻/中度且疾病表现数量较少的患者，而“晚期”硬皮病模式在疾病更严重的形式中更为常见。
这些数据表明毛细血管镜检查在 SSc 管理中的重要性，并且毛细血管镜模式与器官受累的程度直接相关。
