Jiangsu Center of Drug Screening, China Pharmaceutical University, Nanjing 210009, China.
J Ethnopharmacol. 2013 Aug 26;149(1):24-34. doi: 10.1016/j.jep.2013.06.021. Epub 2013 Jun 20.
Recently, biologically active compounds isolated from plants used in herbal medicine have been the center of interest. Deoxypodophyllotoxin (DPT), structurally closely related to the lignan podophyllotoxin, is a potent antitumor and anti-inflammatory agent. However, DPT has not been used clinically yet. Also, DPT from natural sources seems to be unavailable. Hence, it is important to establish alternative resources for the production of such lignan; especially that it is used as a precursor for the semi-synthesis of the cytostatic drugs etoposide phosphate and teniposide.
The update paper provides an overview of DPT as an effective anticancer natural compound and a leader for cytotoxic drugs synthesis and development in order to highlight the gaps in our knowledge and explore future research needs.
The present review covers the literature available from 1877 to 2012. The information was collected via electronic search using Chinese papers and the major scientific databases including PubMed, Sciencedirect, Web of Science and Google Scholar using the keywords. All abstracts and full-text articles reporting database on the history and current status of DPT were gathered and analyzed.
Plants containing DPT have played an important role in traditional medicine. In light of the in vitro pharmacological investigations, DPT is a high valuable medicinal agent that has anti-tumor, anti-proliferative, anti-inflammatory and anti-allergic properties. Further, DPT is an important precursor for the cytotoxic aryltetralin lignan, podophyllotoxin, which is used to obtain semisynthetic derivatives like etoposide and teniposide used in cancer therapy. However, most studies have focused on the in vitro data. Therefore, DPT has not been used clinically yet.
DPT has emerged as a potent chemical agent from herbal medicine. Therefore, in vivo studies are needed to carry out clinical trials in humans and enable the development of new anti-cancer agents. In addition, DPT from commercial sources seems to be unavailable due to its rarity from natural sources and cumbersome extraction procedures. Hence, it is important to establish alternative, cost-effective and renewable resources, such plant cell cultures and (semi-) synthesis strategies for the production of DPT.
最近，来自草药中使用的具有生物活性的植物化合物已成为研究的热点。脱氧鬼臼毒素（DPT）与木脂素鬼臼毒素结构密切相关，是一种有效的抗肿瘤和抗炎剂。然而，DPT 尚未在临床上使用。此外，来自天然来源的 DPT 似乎无法获得。因此，建立此类木脂素的替代资源非常重要；特别是因为它被用作细胞毒性药物依托泊苷磷酸酯和替尼泊苷半合成的前体。
本更新论文概述了 DPT 作为一种有效的抗癌天然化合物和细胞毒性药物合成和开发的先导化合物，以突出我们知识中的空白，并探索未来的研究需求。
本综述涵盖了 1877 年至 2012 年的文献。通过使用中文论文和主要科学数据库（包括 PubMed、Sciencedirect、Web of Science 和 Google Scholar），使用关键字进行电子搜索，收集了信息。收集并分析了所有报告 DPT 历史和现状的数据库的摘要和全文文章。
含有 DPT 的植物在传统医学中发挥了重要作用。鉴于体外药理学研究，DPT 是一种具有高价值的药物，具有抗肿瘤、抗增殖、抗炎和抗过敏特性。此外，DPT 是细胞毒性芳基四氢萘木脂素鬼臼毒素的重要前体，用于获得用于癌症治疗的半合成衍生物依托泊苷和替尼泊苷。然而，大多数研究都集中在体外数据上。因此，DPT 尚未在临床上使用。
DPT 已成为草药中的一种有效化学试剂。因此，需要进行体内研究，以便在人类中进行临床试验并开发新的抗癌药物。此外，由于其在天然来源中的稀有性和繁琐的提取程序，商业来源的 DPT 似乎无法获得。因此，建立替代的、具有成本效益的和可再生的资源非常重要，例如植物细胞培养和（半）合成策略，用于 DPT 的生产。
