Department of Obstetrics and Gynecology, University of Granada, Granada, Spain.
Menopause. 2013 Jul;20(7):754-60. doi: 10.1097/GME.0b013e31827b18c5.
Tibolone is a drug with complex tissue-specific action that exhibits a combination of estrogenic, progestogenic, and slight androgenic activity. Its variable profile explains its clinical effects, depending on the target tissue where it is metabolized, its metabolites' affinity for and potency in hormone receptors, and probable enzymatic activity modulation.In recent reviews and clinical trials, the effectiveness of tibolone in alleviating different hot flush menopause symptoms, mainly in mood and sexuality disorders, has been noted. In Spain, tibolone is the most prescribed hormonal treatment, and one of the most common complaints among postmenopausal women is change in sexual drive. For such reason, a panel of experts from the Spanish Menopause Society met to develop usage recommendations based on the best evidence available.
替勃龙是一种具有复杂组织特异性作用的药物，表现出雌激素、孕激素和轻微雄激素活性的结合。其可变的特征解释了其临床效果，这取决于它在代谢的靶组织、其代谢物对激素受体的亲和力和效力，以及可能的酶活性调节。在最近的综述和临床试验中，已经注意到替勃龙在缓解不同热潮红绝经症状方面的有效性，主要是在情绪和性功能障碍方面。在西班牙，替勃龙是最常被开的激素治疗药物之一，而绝经后妇女最常见的抱怨之一是性欲改变。出于这个原因，来自西班牙绝经学会的专家小组开会制定了基于现有最佳证据的使用建议。
