Guarini S, Tagliavini S, Bazzani C, Ferrari W, Bertolini A
Institute of Pharmacology, University of Modena, Italy.
Crit Care Med. 1990 Aug;18(8):862-5. doi: 10.1097/00003246-199008000-00014.
The ability of ACTH-(1-24) to prolong survival and to extend the deadline for effective blood reinfusion has been studied in a model of lethal hypovolemic shock in the rat. Anesthetized rats were bled to a mean arterial pressure of 18 to 25 mm Hg and then subjected to one of the following iv treatments: a) saline; b) ACTH-(1-24), 160 micrograms/kg; c) blood reinfusion; d) ACTH-(1-24), 160 micrograms/kg; c) blood reinfusion; d) ACTH-(1-24), with saline 5 min after bleeding died within 0.05 h. On the other hand, the treatment with ACTH-(1-24) induced an almost complete and sustained recovery of cardiovascular and respiratory functions associated with a survival time of 44 +/- 18 h, while four of six rats reinfused with the withdrawn blood were still alive 15 days later. The time-lapse between bleeding and treatment was of crucial importance, and neither ACTH-(1-24) injection nor blood reinfusion had any effect if performed 25 min after bleeding. However, treatment with ACTH-(1-24) shortly after bleeding (5 min) greatly improved the effect of a later blood reinfusion. These data indicate that ACTH-(1-24) can prolong survival and permit the time-lapse between blood loss and blood reinfusion to be extended.
促肾上腺皮质激素（1 - 24）延长大鼠致死性低血容量休克模型存活时间以及延长有效输血截止时间的能力已得到研究。将麻醉后的大鼠放血至平均动脉压为18至25毫米汞柱，然后进行以下静脉注射治疗之一：a）生理盐水；b）促肾上腺皮质激素（1 - 24），160微克/千克；c）输血；d）促肾上腺皮质激素（1 - 24），160微克/千克；c）输血；d）促肾上腺皮质激素（1 - 24），放血后5分钟注射生理盐水的大鼠在0.05小时内死亡。另一方面，促肾上腺皮质激素（1 - 24）治疗可使心血管和呼吸功能几乎完全且持续恢复，存活时间为44±18小时，而六只回输所取血液的大鼠中有四只在15天后仍存活。放血与治疗之间的时间间隔至关重要，如果在放血25分钟后进行促肾上腺皮质激素（1 - 24）注射或输血均无效果。然而，放血后不久（5分钟）给予促肾上腺皮质激素（1 - 24）治疗可显著改善随后输血的效果。这些数据表明促肾上腺皮质激素（1 - 24）可延长存活时间，并允许延长失血与输血之间的时间间隔。
