Zhang F X
First Affiliated Hospital, Bethune University of Medical Science, Changchun.
Zhonghua Wai Ke Za Zhi. 1990 Mar;28(3):151-4, 189.
In this study, side-to-side mesocaval shunt (MCS-SS), pericardial devascularization (PCDV), and combined operation of the two procedures were performed in 3 groups of thioacetamide induced liver cirrhotic of rats. Portal and hepatic hemodynamics were investigated on a period of six weeks postoperation, and glucagon concentration in portal vein (PV) and inferior vena cava (IVC) was measured before and six weeks after the surgery. It was found that following PCDV, free portal pressure (FPP) was initially elevated without an increase of total hepatic blood flow (THBF) within four weeks, then both FPP and THBF were shown to decrease on the sixth week. After MCS-SS with a stoma diameter of 2.0mm, a 31% decrease of FPP (P less than 0.05) and a 23% decrease of THBF (P less than 0.05) were observed, though the portal blood flow remained hepatopetal and hyperglucagonemia in PV was not changed. After combined procedure there was a greater decrease of FPP and THBF than that after MCS-SS, and the concentration of glucagon in PV was decreased without any change of its content in IVC.
本研究中，对3组硫代乙酰胺诱导的肝硬化大鼠分别进行了侧侧门腔分流术（MCS - SS）、心包去血管化术（PCDV）以及两种手术的联合操作。在术后六周内对门静脉和肝血流动力学进行了研究，并在手术前及术后六周测量了门静脉（PV）和下腔静脉（IVC）中的胰高血糖素浓度。结果发现，PCDV术后，自由门静脉压（FPP）最初升高，四周内肝总血流量（THBF）未增加，然后在第六周FPP和THBF均下降。在进行了造口直径为2.0mm的MCS - SS后，观察到FPP下降了31%（P小于0.05），THBF下降了23%（P小于0.05），尽管门静脉血流仍向肝，且PV中的高胰高血糖素血症未改变。联合手术后FPP和THBF的下降幅度比MCS - SS后更大，PV中的胰高血糖素浓度降低，而IVC中的含量没有任何变化。
