活性脂质（AL 721）改善宫颈癌患者自然杀伤细胞活性降低的情况。

Improvement of decreased natural killer cell activity in cervical cancer patients by active lipids (AL 721).

作者信息

Garzetti G G, Cignitti M, Marchegiani F, Provinciali M, Zaia A M, Fabris N, Pieri C, Romanini C

机构信息

Department of Obstetrics and Gynaecology, University of Ancona, Italy.

出版信息

Eur J Gynaecol Oncol. 1990;11(2):123-5.

PMID:2379511

Abstract

In the present study we observed the absolute number of NK cells and the NK activity in 10 patients with cervical cancer. NK activity was determined before and after stimulation with Active Lipids. We reported a significant decrease of basal NK activity, but after AL stimulation NK activity was increased with statistical significance. Therefore our findings show that the reduction of NK activity in neoplastic patients is not an irreversible phenomenon since it can be restored by "in vitro" AL administration. This is important for the adoptive immunotherapy by which we could give LAK cells to the patients.

摘要

在本研究中，我们观察了10例宫颈癌患者的自然杀伤细胞（NK细胞）绝对数量及NK活性。在用活性脂质刺激前后测定了NK活性。我们报告基础NK活性显著降低，但在活性脂质刺激后，NK活性有统计学意义的升高。因此，我们的研究结果表明，肿瘤患者NK活性的降低并非不可逆转的现象，因为它可通过“体外”给予活性脂质得以恢复。这对于我们可给患者输注淋巴因子激活的杀伤细胞（LAK细胞）的过继性免疫治疗很重要。