Rozga J, Flati G, Tenenbaum A, Andersson L, Jeppsson B, Bengmark S
Department of Surgery, University of Lund, Sweden.
Eur Surg Res. 1990;22(1):34-40. doi: 10.1159/000129080.
The effect of portacaval shunt (PCS) with and without hepatic arterialization (HA) upon the liver morphology, hemodynamics, and in relation to testicular weight, histology, and plasma sex steroid levels has been investigated in male rats. PCS rats showed a significant decrease in hepatic blood flow, body and liver weights, together with signs of severe hypogonadism. In contrast, in HA rats the increment in liver blood flow was associated with higher body and liver weights. In spite of total portal blood shunting, a beneficial effect on testicular morphology and an increase in plasma testosterone level were observed. In respect to plasma estradiol levels the intergroup differences could not be evaluated due to large individual variations. This was probably caused by the presence of cross-reactive plasma component(s) masking the level of endogenous estrogen. It is concluded that portosystemic shunting is not of primary importance in the etiology of PCS-related hypogonadism in the male.
在雄性大鼠中，研究了有或无肝动脉化（HA）的门腔分流术（PCS）对肝脏形态、血流动力学以及与睾丸重量、组织学和血浆性类固醇水平的关系的影响。PCS大鼠的肝血流量、体重和肝脏重量显著降低，同时伴有严重性腺功能减退的迹象。相比之下，HA大鼠的肝脏血流量增加与更高的体重和肝脏重量相关。尽管门静脉血完全分流，但观察到对睾丸形态有有益影响，且血浆睾酮水平升高。关于血浆雌二醇水平，由于个体差异较大，无法评估组间差异。这可能是由于存在交叉反应性血浆成分掩盖了内源性雌激素水平所致。结论是，门体分流在男性PCS相关性性腺功能减退的病因中并非首要因素。
