Grün R, Grün M, Ehlenz K, Chari S, Kaffarnik H
Z Gastroenterol. 1984 Jan;22(1):30-41.
Portocaval anastomosis (PCA) in the normal male rat causes profound alterations in testicular morphology and function and in plasma levels of sex steroids as well as of gonadotropins. Testicular atrophy is accompanied by a significant decrease of plasma testosterone (0.03 ng/ml versus 0.99 ng/ml) and an increase of estradiol (76.2 pg/ml versus 39.7 pg/ml) and estrone (68. pg/ml versus 45.5 pg/ml). Plasma levels of gonadotropins (LH, FSH) and prolactin are lowered too (LH: 15 ng/ml versus 28.5 ng/ml, FSH:119 versus 182 ng/ml, prolactin:53 versus 109 ng/ml). The altered sex hormone metabolism is reflected in marked changes of the morphology and nucleic acid content of the metabolizing organs i.e. liver, gonades and kidney. The results of this study are consistent with the hypothesis that portosystemic shunt per se plays an important role in the pathogenesis of the disturbed metabolism of sex hormones observed in patients with liver cirrhosis and portal hypertension.
正常雄性大鼠的门腔静脉吻合术（PCA）会导致睾丸形态和功能以及血浆中性类固醇、促性腺激素水平发生深刻变化。睾丸萎缩伴随着血浆睾酮显著降低（从0.99 ng/ml降至0.03 ng/ml）以及雌二醇（从39.7 pg/ml升至76.2 pg/ml）和雌酮（从45.5 pg/ml升至68 pg/ml）升高。促性腺激素（LH、FSH）和催乳素的血浆水平也降低（LH：从28.5 ng/ml降至15 ng/ml，FSH：从182 ng/ml降至119 ng/ml，催乳素：从109 ng/ml降至53 ng/ml）。性激素代谢的改变反映在代谢器官即肝脏、性腺和肾脏的形态及核酸含量的显著变化上。本研究结果与以下假设一致，即门体分流本身在肝硬化和门静脉高压患者中观察到的性激素代谢紊乱的发病机制中起重要作用。
