School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
Langmuir. 2013 Jul 23;29(29):9156-63. doi: 10.1021/la402119s. Epub 2013 Jul 8.
Highly cross-linked and biocompatible poly(cyclotriphosphazene-co-4,4'-sulfonyldiphenol) (PZS) were used to directly coat hydrophilic superparamagnetic Fe3O4 nanoparticles by a facile but effective one-pot polycondensation. The obtained core-shell Fe3O4@PZS nanohybrids were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction spectra. Interesting, the size and T2 relaxivity of Fe3O4@PZS increased with increasing the mass ratio of Fe3O4 to PZS. All these nanohybrids could be internalized by HeLa cells but show negligible cytotoxicity. The PZS layer slowly degraded into less dangerous forms such as 4,4'-sulfonyldiphenol, phosphate and ammonia at neutral or acid atmosphere. Considering their excellent water dispersibility, colloidal and chemical stability, magnetic manipulation, and magnetic resonance imaging (MRI) properties, Fe3O4@PZS nanohybrids have great potential in MRI diagnosis of cancer.
采用高度交联和生物相容的聚（环三磷腈-4,4'-磺酰二苯酚）（PZS）通过简便有效的一锅聚缩合法直接包覆亲水性超顺磁性 Fe3O4 纳米粒子。通过透射电子显微镜（TEM）、扫描电子显微镜（SEM）、傅里叶变换红外（FTIR）和 X 射线衍射光谱对所得核壳 Fe3O4@PZS 纳米杂化物进行了表征。有趣的是，随着 Fe3O4 与 PZS 的质量比的增加，Fe3O4@PZS 的尺寸和 T2 弛豫率增大。所有这些纳米杂化物都可以被 HeLa 细胞内化，但表现出可以忽略不计的细胞毒性。在中性或酸性环境中，PZS 层缓慢降解为更危险的形式，如 4,4'-磺酰二苯酚、磷酸盐和氨。考虑到它们优异的水分散性、胶体和化学稳定性、磁操控和磁共振成像（MRI）性能，Fe3O4@PZS 纳米杂化物在癌症的 MRI 诊断中具有巨大的潜力。
