Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
AJR Am J Roentgenol. 2013 Aug;201(2):264-77. doi: 10.2214/AJR.13.10713. Epub 2013 Jun 24.
A review of the innovative role molecular imaging plays in musculoskeletal radiology is provided. Musculoskeletal molecular imaging is under development in four key areas: imaging the activity of osteoblasts and osteoclasts, imaging of molecular and cellular biomarkers of arthritic joint destruction, cellular imaging of osteomyelitis, and imaging generators of musculoskeletal pain.
Together, these applications suggest that next-generation musculoskeletal radiology will facilitate quantitative visualization of molecular and cellular biomarkers, an advancement that appeared futuristic just a decade ago.
本文综述了分子影像学在肌肉骨骼放射学中的创新作用。肌肉骨骼分子影像学在四个关键领域得到了发展:成骨细胞和破骨细胞活性的成像、关节炎关节破坏的分子和细胞生物标志物的成像、骨髓炎的细胞成像以及肌肉骨骼疼痛产生源的成像。
这些应用共同表明,下一代肌肉骨骼放射学将有助于对分子和细胞生物标志物进行定量可视化,这一进步在十年前似乎还很遥远。