Kogan Feliks, Fan Audrey P, Gold Garry E
Department of Radiology, Stanford University, Stanford, California, USA.
Department of Radiology, Stanford University, Stanford, California, USA; Department of Bioengineering, Stanford University, Stanford, California, USA; Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.
Quant Imaging Med Surg. 2016 Dec;6(6):756-771. doi: 10.21037/qims.2016.12.16.
Early detection of musculoskeletal disease leads to improved therapies and patient outcomes, and would benefit greatly from imaging at the cellular and molecular level. As it becomes clear that assessment of multiple tissues and functional processes are often necessary to study the complex pathogenesis of musculoskeletal disorders, the role of multi-modality molecular imaging becomes increasingly important. New positron emission tomography-magnetic resonance imaging (PET-MRI) systems offer to combine high-resolution MRI with simultaneous molecular information from PET to study the multifaceted processes involved in numerous musculoskeletal disorders. In this article, we aim to outline the potential clinical utility of hybrid PET-MRI to these non-oncologic musculoskeletal diseases. We summarize current applications of PET molecular imaging in osteoarthritis (OA), rheumatoid arthritis (RA), metabolic bone diseases and neuropathic peripheral pain. Advanced MRI approaches that reveal biochemical and functional information offer complementary assessment in soft tissues. Additionally, we discuss technical considerations for hybrid PET-MR imaging including MR attenuation correction, workflow, radiation dose, and quantification.
肌肉骨骼疾病的早期检测有助于改善治疗方法和患者预后，且在细胞和分子水平成像将使其受益匪浅。随着越来越清楚地认识到，研究肌肉骨骼疾病的复杂发病机制通常需要对多个组织和功能过程进行评估，多模态分子成像的作用变得越来越重要。新型正电子发射断层扫描-磁共振成像（PET-MRI）系统能够将高分辨率MRI与来自PET的同步分子信息相结合，以研究多种肌肉骨骼疾病中涉及的多方面过程。在本文中，我们旨在概述PET-MRI联合成像对这些非肿瘤性肌肉骨骼疾病的潜在临床应用价值。我们总结了PET分子成像在骨关节炎（OA）、类风湿关节炎（RA）、代谢性骨病和神经性外周疼痛中的当前应用。能够揭示生化和功能信息的先进MRI方法为软组织提供了补充评估。此外，我们还讨论了PET-MR联合成像的技术考量，包括MR衰减校正、工作流程、辐射剂量和定量分析。
