College of Animal Science and Technology, Henan Science and Technology University , Luoyang , China .
Int J Food Sci Nutr. 2013 Nov;64(7):822-9. doi: 10.3109/09637486.2013.803520. Epub 2013 Jun 25.
Genotypic variation of iron bioavailability and the relationship between iron bioavailability and nutrient composition in polished rice among 11 rice genotypes were assessed using an in vitro digestion/Caco-2 cell model. The results indicated that significant differences in iron bioavailability were detected among tested rice genotypes, with a 3-fold range, suggesting a possibility of selecting high bioavailable iron by plant breeding. Although iron bioavailability was not significantly correlated with Fe concentration in polished rice among tested rice genotypes, the results also indicated that most of the iron dense genotypes showed relatively high ferritin formation in Caco-2 cell and transported iron. Additionally, iron bioavailability in polished rice was enhanced by addition of ascorbic acid, with a much wider range of Fe bioavailability variation in polished rice with addition of ascorbic acid than that without addition of ascorbic acid. The positive relationship between iron bioavailability in polished rice and cysteine concentration (R = 0.669) or sulfur (S) concentration (R = 0.744) among tested rice genotypes, suggests that cysteine and sulfur concentration in polished rice could be used as an indicator for high iron bioavailability.
采用体外消化/Caco-2 细胞模型评估了 11 种水稻基因型中抛光稻米中铁的生物利用度的基因型变异以及铁的生物利用度与营养成分之间的关系。结果表明，在所测试的水稻基因型中，铁的生物利用度存在显著差异，范围为 3 倍，这表明通过植物育种选择高铁生物利用度是有可能的。尽管在所测试的水稻基因型中，铁的生物利用度与抛光稻米中的铁浓度没有显著相关，但结果还表明，大多数铁密集基因型在 Caco-2 细胞中形成相对较高的铁蛋白并转运铁。此外，在添加抗坏血酸的情况下，抛光稻米中的铁生物利用度得到提高，添加抗坏血酸的情况下，抛光稻米中铁的生物利用度变化范围比不添加抗坏血酸的情况下要宽得多。在所测试的水稻基因型中，抛光稻米中铁的生物利用度与半胱氨酸浓度（R=0.669）或硫（S）浓度（R=0.744）之间存在正相关关系，这表明抛光稻米中的半胱氨酸和硫浓度可用作高铁生物利用度的指标。
