Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University , Namku, Taegu , Republic of Korea.
Int J Neurosci. 2013 Dec;123(12):892-5. doi: 10.3109/00207454.2013.810627. Epub 2013 Jul 9.
We report on a patient with hemorrhage of the corpus callosum (CC) in whom unusual compensatory neural connections were observed following disruption of CC fibers.
A 42-year-old female patient presented with callosal alien hand syndrome (AHS) after the onset of the hemorrhage. She showed a rapid recovery and the symptoms of her AHS had almost disappeared at 7 weeks after onset. We performed diffusion tensor tractography (DTT) for the evaluation of CC fibers and performed a comparison with DTT findings acquired from a normal subject (a 47-year-old female).
Findings on DTT of the patient revealed extensive disruption of CC fibers passing through the anterior portion of the genu and most of the CC body. We observed that CC fibers in the right and left temporal lobes joined with the right and left inferior fronto-occipital fasciculus, respectively, and these neural fibers were connected to each other through the anterior commissure. These changes of neural connections were not observed in the normal subject.
We think that the unusual neural connections in this patient were compensatory phenomena for disruption of CC fibers. In addition, the good recovery from symptoms of AHS in this patient appears to be correlated with these unusual compensatory neural connections. We believe that the results of this study suggest a mechanism for neural recovery following injury of the CC fibers.
我们报告了一例因胼胝体纤维中断而出现胼胝体出血的患者，其出现了异常的代偿性神经连接。
一名 42 岁女性患者在出血后出现了胼胝体异体手综合征（AHS）。她恢复迅速，发病后 7 周时 AHS 症状几乎消失。我们对胼胝体纤维进行了弥散张量纤维束成像（DTT）检查，并与一名正常受试者（47 岁女性）的 DTT 结果进行了比较。
患者的 DTT 检查结果显示，胼胝体纤维在前部膝部和大部分胼胝体体部广泛中断。我们观察到，右侧和左侧颞叶的胼胝体纤维分别与右侧和左侧额枕下束相连，这些神经纤维通过前连合相互连接。这些神经连接的变化在正常受试者中未观察到。
我们认为该患者异常的神经连接是胼胝体纤维中断的代偿现象。此外，该患者 AHS 症状的良好恢复似乎与这些异常的代偿性神经连接有关。我们认为，本研究的结果提示了胼胝体纤维损伤后神经恢复的机制。
