Chen J, Kwong D L, Cao T, Hu Q, Zhang L, Ming X, Chen J, Fu L, Guan X
Departments of Clinical Oncology, The University of Hong Kong, Hong Kong; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dis Esophagus. 2015 Jan;28(1):84-9. doi: 10.1111/dote.12088. Epub 2013 Jun 24.
Esophageal cancer is aggressive and has poor prognosis. Esophageal squamous cell carcinoma (ESCC) is histologically the most prevalent type of esophageal cancer and ranked as the sixth leading cause of cancer death worldwide. In recent years, cancer has been widely regarded as genetic disease, as well as epigenetic abnormalities including DNA methylation, histone deacetylation, chromatin remodeling, gene imprinting and noncoding RNA regulation. In this review, we will provide a general overview of genes, proteins and microRNAs that are involved in the development of ESCC, which aims to enhance our understanding of molecular mechanisms implicated in ESCC development and progression.
食管癌具有侵袭性，预后较差。食管鳞状细胞癌（ESCC）在组织学上是食管癌最常见的类型，是全球癌症死亡的第六大主要原因。近年来，癌症已被广泛视为一种遗传疾病，以及包括DNA甲基化、组蛋白去乙酰化、染色质重塑、基因印记和非编码RNA调控在内的表观遗传异常。在本综述中，我们将概述参与ESCC发生发展的基因、蛋白质和微小RNA，旨在加深我们对ESCC发生发展和进展所涉及分子机制的理解。
