Karande V C, Scott R T, Archer D F
Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
Fertil Steril. 1990 Aug;54(2):217-21.
The present study was designed to evaluate the effect of different serum concentrations of estradiol-17 beta (E2) on pituitary luteinizing hormone (LH) release in postmenopausal women. Serum E2 levels were evaluated in healthy postmenopausal women while they wore two, four, and six transdermal E2 delivery systems. The mean serum E2 levels at 48 hours after application of the devices were 185.5, 338.9, and 520.5 pg/mL, respectively, which were significantly different from each other. Serum E2 levels were stable throughout the first 48 hours of patch application but declined by a mean of 54% between 48 and 72 hours. Pituitary LH surges were induced with all three serum concentrations of E2 but were present more often with the higher serum values. There were no significant differences between the mean interval of device utilization and initiation, height, or duration of the induced pituitary LH surge at any of the three serum E2 concentrations studied.
本研究旨在评估不同血清浓度的17β-雌二醇（E2）对绝经后女性垂体促黄体生成素（LH）释放的影响。在健康绝经后女性佩戴两个、四个和六个经皮E2递送系统时，对其血清E2水平进行评估。在应用这些装置48小时后的平均血清E2水平分别为185.5、338.9和520.5 pg/mL，彼此之间有显著差异。在贴片应用的前48小时内血清E2水平稳定，但在48至72小时之间平均下降了54%。所有三种血清浓度的E2均诱导出垂体LH激增，但在血清值较高时出现的频率更高。在所研究的三种血清E2浓度中的任何一种下，装置使用与诱导垂体LH激增开始之间的平均间隔、高度或持续时间均无显著差异。
