Mountain Research Center (ESA), Polytechnic Institute of Braganca, Apartado 1172, 5301-855 Braganca, Portugal.
Anticancer Agents Med Chem. 2013 Oct;13(8):1236-58. doi: 10.2174/18715206113139990301.
Cancer is a worldwide scourge; it's the leading cause of death in developed countries and is increasing in developing countries. Mankind has been trying with effort to find better and cheaper treatments with fewer side effects, to reduce the incidence of the disease and its consequent mortality. For many years, phenolic compounds have been intensely studied for their antitumor, proapoptotic and antiangiogenic effects. In recent years, the usage of these compounds has increased considerably. This manuscript intends to structurally characterize the different phenolic compounds (flavonoids, hydroxycinnamates, hydroxybenzoates, coumarins, xanthones, chalcones, stilbenes, lignins and lignans) and their metabolic pathways as well as review the most important results regarding these compounds and their derivatives in cancer treatment and prevention both in tumor cell lines in vitro, in murine models in vivo and finally some results regarding human trials.
癌症是一种全球性的祸害；它是发达国家的主要死亡原因，在发展中国家也呈上升趋势。人类一直在努力寻找更好、更便宜、副作用更小的治疗方法，以降低疾病的发病率和死亡率。多年来，人们一直在深入研究酚类化合物的抗肿瘤、促凋亡和抗血管生成作用。近年来，这些化合物的使用量大大增加。本文旨在对不同的酚类化合物（类黄酮、羟基肉桂酸、羟基苯甲酸、香豆素、酮、查耳酮、二苯乙烯、木质素和木脂素）及其代谢途径进行结构表征，并综述这些化合物及其衍生物在癌症治疗和预防中的重要研究结果，包括体外肿瘤细胞系、体内小鼠模型以及一些关于人体试验的结果。
