Pluribus Systems, Durham, NC, USA.
J Theor Biol. 2013 Oct 7;334:162-72. doi: 10.1016/j.jtbi.2013.05.030. Epub 2013 Jun 22.
Although the basic mechanics of evolution have been understood since Darwin, debate continues over whether macroevolutionary phenomena are driven by the fitness structure of genotype space or by ecological interaction. In this paper we propose a simple model capturing key features of fitness-landscape and ecological models of evolution. Our model describes evolutionary dynamics in a high-dimensional, structured genotype space with interspecies interaction. We find promising qualitative similarity with the empirical facts about macroevolution, including broadly distributed extinction sizes and realistic exploration of the genotype space. The abstraction of our model permits numerous applications beyond macroevolution, including protein and RNA evolution.
尽管达尔文以来人们已经了解了进化的基本机制，但关于宏观进化现象是由基因型空间的适合度结构驱动还是由生态相互作用驱动，仍存在争议。在本文中，我们提出了一个简单的模型，该模型捕捉了适合度景观和进化生态模型的关键特征。我们的模型描述了具有种间相互作用的高维结构化基因型空间中的进化动态。我们发现与宏观进化的经验事实具有有希望的定性相似性，包括广泛分布的灭绝规模和对基因型空间的现实探索。我们模型的抽象允许超越宏观进化的众多应用，包括蛋白质和 RNA 进化。
