Institute of Clinical Microbiology, Albert Szent-Györgyi Clinical Center, Faculty of Medicine, University of Szeged, Semmelweis 6, H-6725 Szeged, Hungary.
Anaerobe. 2013 Oct;23:70-3. doi: 10.1016/j.anaerobe.2013.06.008. Epub 2013 Jun 22.
We detected four cfiA-bft1 doubly positive Bacteroides fragilis strains out of 486 B. fragilis isolates analyzed for antibiotic susceptibilities and antibiotic resistance genes from a recent pan-European survey. The prevalence of the enterotoxin bft genes was roughly equal among cfiA-negative and -positive B. fragilis strains. We also demonstrated that the cfiA-bft doubly positive strains had the most common B. fragilis genomic pattern (I.1.). Thus we concluded that the bft-carrying CTn86 conjugative transposons are mobile accounting for this unexpected simultaneous occurrence of the cfiA and bft genes.
我们从最近的一项泛欧调查中分析了 486 株脆弱拟杆菌分离株的抗生素药敏性和抗生素耐药基因，发现了 4 株 cfiA-bft1 双重阳性脆弱拟杆菌菌株。cfiA 阴性和阳性脆弱拟杆菌菌株中肠毒素 bft 基因的流行率大致相等。我们还证明，cfiA-bft 双重阳性菌株具有最常见的脆弱拟杆菌基因组模式（I.1.）。因此，我们得出结论，携带 bft 的 CTn86 可移动性接合转座子是造成 cfiA 和 bft 基因同时出现的原因。
