Sampogna Francesca
Health Services Research Unit, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy.
Curr Probl Dermatol. 2013;44:47-51. doi: 10.1159/000350781. Epub 2013 May 24.
The concepts of cumulative life course impairment (CLCI) and health-related quality of life (QoL) are analyzed, in order to find shared and divergent aspects. The concept of QoL includes the patients' perception of their health and their personal experiences concerning the psychosocial impact of the disease on their life. CLCI aims to investigate the impact of a chronic disease on the milestones of life, such as education, work, relationships, children, social life, (briefly - on the whole trajectory of life) and on how the disease influenced the possibility of patients of living their life up to its full potential. QoL is a cross-sectional measure, while CLCI takes into account the lifetime. However, it is clear that the possibility of reaching one's full life potential and QoL at a certain time are correlated. There are few studies in dermatology in this field; however, both in the case of atopic dermatitis and of vitiligo it has been shown that patients with a severe condition in childhood endured severe psychosocial and physical consequences in adulthood and experienced a profound negative impact of the disease on their current quality of life. It is thus important to take into account both CLCI and QoL when evaluating the impact of a chronic condition on a patient's life.
为了找出共同和不同的方面，对累积生命历程损伤（CLCI）和健康相关生活质量（QoL）的概念进行了分析。生活质量的概念包括患者对自身健康的认知以及他们关于疾病对其生活的心理社会影响的个人经历。CLCI旨在研究慢性病对生活里程碑的影响，如教育、工作、人际关系、子女、社交生活（简而言之——对整个生命轨迹），以及疾病如何影响患者充分发挥生活潜力的可能性。生活质量是一种横断面测量方法，而CLCI考虑的是一生的情况。然而，很明显，在某个时间充分发挥生命潜力的可能性与生活质量是相关的。在皮肤病学领域，这方面的研究很少；然而，无论是特应性皮炎还是白癜风，都已表明童年时期病情严重的患者在成年后承受了严重的心理社会和身体后果，并且疾病对他们当前的生活质量产生了深远的负面影响。因此，在评估慢性病对患者生活的影响时，同时考虑CLCI和QoL是很重要的。
