4'-乙炔基-2-氟-2'-脱氧腺苷与临床使用的抗逆转录病毒药物联合应用的评估
Evaluation of Combinations of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Clinically Used Antiretroviral Drugs.
作者信息
Hachiya Atsuko, Reeve Aaron B, Marchand Bruno, Michailidis Eleftherios, Ong Yee Tsuey, Kirby Karen A, Leslie Maxwell D, Oka Shinichi, Kodama Eiichi N, Rohan Lisa C, Mitsuya Hiroaki, Parniak Michael A, Sarafianos Stefan G
机构信息
Christopher Bond Life Sciences Center, Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, USA.
AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 2013 Sep;57(9):4554-4558. doi: 10.1128/AAC.00283-13. Epub 2013 Jun 24.
Abstract
Drug combination studies of 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) with FDA-approved drugs were evaluated by two different methods, MacSynergy II and CalcuSyn. Most of the combinations, including the combination of the two adenosine analogs EFdA and tenofovir, were essentially additive, without substantial antagonism or synergism. The combination of EFdA and rilpivirine showed apparent synergism. These studies provide information that may be useful for the design of EFdA combination regimens for initial and salvage therapy assessment.
摘要
采用两种不同方法MacSynergy II和CalcuSyn对4'-乙炔基-2-氟-2'-脱氧腺苷（EFdA）与FDA批准药物的联合用药研究进行了评估。大多数联合用药，包括两种腺苷类似物EFdA和替诺福韦的联合用药，本质上是相加作用，没有明显的拮抗或协同作用。EFdA和利匹韦林的联合用药表现出明显的协同作用。这些研究提供的信息可能有助于设计用于初始治疗和挽救治疗评估的EFdA联合用药方案。
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