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Selective inhibition of thymidine kinase isoenzymes by (E)-5-(2-bromovinyl)-2-deoxyuridine.

作者信息

Armstrong B, Modjtahedi H, O'Neill K L, Hannigan B M, McKenna P G

机构信息

Biomedical Sciences Research Centre, University of Ulster, Coleraine, Ireland, U.K.

出版信息

Biochem Soc Trans. 1990 Apr;18(2):270. doi: 10.1042/bst0180270.

DOI:10.1042/bst0180270
PMID:2379709
Abstract
摘要

相似文献

1
Selective inhibition of thymidine kinase isoenzymes by (E)-5-(2-bromovinyl)-2-deoxyuridine.(E)-5-(2-溴乙烯基)-2-脱氧尿苷对胸苷激酶同工酶的选择性抑制作用
Biochem Soc Trans. 1990 Apr;18(2):270. doi: 10.1042/bst0180270.
2
Thymidine kinase activities in mononuclear leukocytes and serum from breast cancer patients.乳腺癌患者单核白细胞和血清中的胸苷激酶活性。
Br J Cancer. 1988 Jun;57(6):619-22. doi: 10.1038/bjc.1988.141.
3
Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.碳环5-碘-2'-脱氧尿苷(C-IDU)和碳环(E)-5-(2-溴乙烯基)-2'-脱氧尿苷(C-BVDU)是手性分子的独特例子,其中两种对映体形式都具有生物活性:C-IDU和C-BVDU的(+)-和(-)-对映体与单纯疱疹病毒1型胸苷激酶的相互作用。
Mol Pharmacol. 1990 Mar;37(3):395-401.
4
Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.(E)-5-(2-溴乙烯基)-2'-脱氧尿苷及相关化合物对单纯疱疹病毒1型胸苷激酶基因转化的小鼠乳腺FM3A癌细胞增殖的选择性抑制作用
Nucleic Acids Symp Ser. 1985(16):283-6.
5
Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.(E)-5-(2-溴乙烯基)-2'-脱氧尿苷(BVDU)及相关化合物对单纯疱疹病毒(HSV)感染细胞和HSV胸苷激酶基因转化细胞的抑制作用。
Methods Find Exp Clin Pharmacol. 1989 Jun;11(6):379-89.
6
Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts.溴乙烯基脱氧尿苷:细胞提取物中线粒体胸苷激酶的一种选择性底物。
Biochem Biophys Res Commun. 2006 May 26;344(1):30-6. doi: 10.1016/j.bbrc.2006.03.147.
7
A comparison of the conformations adopted by some 5-bromovinyl-2'-deoxyuridines and a correlation with their antiviral properties: an X-ray study.某些5-溴乙烯基-2'-脱氧尿苷所采用构象的比较及其与抗病毒特性的相关性:一项X射线研究。
Nucleic Acids Res. 1987 May 26;15(10):4111-21. doi: 10.1093/nar/15.10.4111.
8
Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.(E)-5-(2-溴乙烯基)-2'-脱氧尿苷(BVDU)及其阿拉伯糖基衍生物(E)-5-(2-溴乙烯基)-1-β-D-阿拉伯呋喃糖基尿嘧啶(BVaraU)对表达水痘带状疱疹病毒或单纯疱疹病毒胸苷激酶的肿瘤细胞的体外和体内比较细胞毒性活性。
Cancer Gene Ther. 2000 Feb;7(2):215-23. doi: 10.1038/sj.cgt.7700108.
9
Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.用1型单纯疱疹病毒胸苷激酶基因转化的小鼠乳腺FM3A癌细胞对(E)-5-(2-溴乙烯基)-2'-脱氧尿苷及相关化合物的生长抑制特性高度敏感。
FEBS Lett. 1985 Jun 3;185(1):95-100. doi: 10.1016/0014-5793(85)80747-x.
10
Increased sensitivity of thymidine kinase-deficient (TK-) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds.胸苷激酶缺陷(TK-)肿瘤细胞系对(E)-5-(2-溴乙烯基)-2'-脱氧尿苷(BVDU)及相关化合物的细胞生长抑制作用敏感性增加。
Anticancer Res. 1986 Sep-Oct;6(5):1077-84.