McKenna P G, O'Neill K L, Abram W P, Hannigan B M
Biomedical Sciences Research Centre, University of Ulster, Coleraine, Northern Ireland.
Br J Cancer. 1988 Jun;57(6):619-22. doi: 10.1038/bjc.1988.141.
Levels of the nucleotide pathway enzyme thymidine kinase (TK) were assayed in the mononuclear leukocytes and serum of 70 female patients with breast cancer and 98 male and 77 female non-cancer hospital patients. The total TK levels in both mononuclear leukocytes and serum from patients with breast cancer were significantly higher than in controls. The serum TK levels showed a significant correlation with cancer stage. No such correlation was observed with mononuclear leukocyte TK levels. Serum TK from 20 patients with breast cancer and 19 control patients was further assayed to ascertain the relative contributions of the thymidine kinase isozymes TK1 and TK2 to total TK levels. The increase in serum TK from breast cancer patients appears to be due to an increase in both TK1 and TK2 levels.
在70例女性乳腺癌患者以及98例男性和77例女性非癌症医院患者的单核白细胞和血清中检测了核苷酸途径酶胸苷激酶（TK）的水平。乳腺癌患者单核白细胞和血清中的总TK水平均显著高于对照组。血清TK水平与癌症分期显著相关。单核白细胞TK水平未观察到这种相关性。对20例乳腺癌患者和19例对照患者的血清TK进行了进一步检测，以确定胸苷激酶同工酶TK1和TK2对总TK水平的相对贡献。乳腺癌患者血清TK的升高似乎是由于TK1和TK2水平均升高所致。
