Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Obes Facts. 2013;6(3):288-96. doi: 10.1159/000353641. Epub 2013 Jun 22.
To determine if length of first stay impacts on weight loss and cardiovascular fitness, at 1 and 2 years in severely obese patients enrolled in intermittent residential programs.
In a retrospective follow-up study, we assessed weight loss and changes in cardiovascular fitness (VO₂ peak) at 1 and 2 years in 179 severely obese adults who participated in two intermittent residential programmes. Both programmes consisted of five stays at the Røros Rehabilitation Centre over a 2-year period, but programme A consisted of a much longer first stay compared with programme B (8 vs. 2 weeks).
Of 179 participants (BMI 44 ± 6 kg/m²), 162 completed 1-year and 117 2-year evaluation. Programme A led to significantly larger weight reduction (-20.7 ± 10.8 vs. -13.5 ± 8.1 kg and -16.0 ± 12.7 vs. -7.9 ± 11.2 kg, p < 0.0001) and improvement in VO₂ peak (7.8 vs. 3.6 ml/kg/min (p < 0.0001) and 5.6 vs. 2.5 ml/kg/min (p < 0.01)) at both 1 and 2 years, compared with programme B. Intention-to-treat analysis showed similar results.
A residential intermittent programme with a longer initial stay is associated with better weight loss and improvement in cardiovascular fitness at both 1 and 2 years. A longer follow-up is needed to clearly establish the sustainability of these programmes.
在参加间歇性住院计划的严重肥胖患者中，确定首次住院时间的长短对 1 年和 2 年时的体重减轻和心血管健康的影响。
在一项回顾性随访研究中，我们评估了 179 名严重肥胖成年人在参加两个间歇性住院计划的 1 年和 2 年时的体重减轻和心血管健康（VO₂峰值）的变化。两个计划都包括在 2 年内 5 次入住罗罗斯康复中心，但计划 A 的首次住院时间比计划 B 长得多（8 周与 2 周）。
在 179 名参与者中（BMI 44 ± 6 kg/m²），162 名完成了 1 年的评估，117 名完成了 2 年的评估。与计划 B 相比，计划 A 导致体重明显减轻（-20.7 ± 10.8 与-13.5 ± 8.1 kg 和-16.0 ± 12.7 与-7.9 ± 11.2 kg，p < 0.0001）和 VO₂峰值改善（7.8 与 3.6 ml/kg/min（p < 0.0001）和 5.6 与 2.5 ml/kg/min（p < 0.01））在 1 年和 2 年均有显著改善。意向治疗分析显示了类似的结果。
与计划 B 相比，住院间歇性计划中初始住院时间较长与 1 年和 2 年时更好的体重减轻和心血管健康改善相关。需要更长的随访时间来明确这些计划的可持续性。
