Department of Periodontology and Oral Diseases, Medical University of Warsaw, Warsaw, Poland.
Kardiol Pol. 2013;71(6):600-5. doi: 10.5603/KP.2013.0124.
Cardiovascular diseases as well as periodontitis can be regarded as current epidemics and have become a social problem. Mean platelet volume (MPV) is a simple, routinely assessed biochemical parameter, which is becoming regarded asa new, independent risk factor of acute coronary syndromes and stroke.
Assessment of a potential relationship between clinical indices of periodontal disease and MPV in relation to the presence of coronary artery disease (CAD) and chronic periodontitis.
The study included 57 individuals aged from 50 to 65 years. Patients were divided into three groups. Group 1 consisted of 19 patients with previously diagnosed CAD and coexisting chronic periodontitis. Group 2 included 18 patients with diagnosed chronic periodontitis with excluded CAD. Group 3 was a control group and consisted of 20 healthy individuals without CAD or periodontitis.
Unsatisfactory oral hygiene defined by plaque index (PI) was observed in all patients. Mean PI was significantly higher in Groups 1 and 2 than in Group 3 (76.7% vs. 45.7%, p < 0.01). Mean bleeding index (BI) was significantly higher in Group 2 than in Groups 1 and 3 (46.4% vs. 29.8%, p < 0.05). Mean periodontal pocket depths (PD) (2.75 mm, 2.93 mm,1.97 mm, respectively, p < 0.05, p < 0.01) and clinical attachment loss (CAL) were significantly higher in Groups 1 and 2 than in Group 3 (5.13 mm, 4.79 mm, 1.31 mm, respectively, p < 0.01). Mean WBC, fibrinogen and hsCRP were not significantly different among the examined groups (WBC 6.81 G/L vs. 6.71 G/L vs. 6.18 G/L, fibrinogen concentration 4.31 g/L vs. 3.94 g/L vs. 3.67 g/L; hsCRP concentration 4.08 mg/dL vs. 6.61 mg/dL vs. 4.33 mg/dL). In Group 1, MPV was significantly higher than in Group 3 (10.39 fL vs. 9.39 fL, p < 0.01). There was a weak, although significant, correlation between periodontal parameters and MPV and correlations between MPV and PD as well as CAL (MPV-PD: r = 0.45, p < 0.05; MPV-CAL: r = 0.42, p < 0.05).
Chronic periodontitis in patients with CAD results in an increased MPV that may suggest increased platelet activity. This observation could indicate a potential pathophysiological link between chronic periodontitis and an increased risk of acute coronary syndromes.
心血管疾病和牙周炎可被视为当前的流行病，已成为社会问题。平均血小板体积（MPV）是一种简单的、常规评估的生化参数，它被认为是急性冠状动脉综合征和中风的一个新的独立危险因素。
评估牙周病的临床指标与血小板平均体积（MPV）之间的潜在关系，以及它们与冠心病（CAD）和慢性牙周炎的关系。
本研究纳入了 57 名年龄在 50 岁至 65 岁之间的个体。患者被分为三组。第 1 组包括 19 名患有先前诊断的 CAD 且合并慢性牙周炎的患者。第 2 组包括 18 名患有诊断明确的慢性牙周炎且排除 CAD 的患者。第 3 组为对照组，由 20 名无 CAD 或牙周炎的健康个体组成。
所有患者的菌斑指数（PI）均显示口腔卫生状况不佳。第 1 组和第 2 组的平均 PI 明显高于第 3 组（76.7%比 45.7%，p < 0.01）。第 2 组的平均出血指数（BI）明显高于第 1 组和第 3 组（46.4%比 29.8%，p < 0.05）。第 1 组和第 2 组的平均牙周袋深度（PD）（分别为 2.75 mm、2.93 mm、1.97 mm，p < 0.05、p < 0.01）和临床附着丧失（CAL）明显高于第 3 组（分别为 5.13 mm、4.79 mm、1.31 mm，p < 0.01）。检查各组之间的白细胞（WBC）、纤维蛋白原和高敏 C 反应蛋白（hsCRP）没有显著差异（WBC 6.81 G/L 比 6.71 G/L 比 6.18 G/L，纤维蛋白原浓度 4.31 g/L 比 3.94 g/L 比 3.67 g/L；hsCRP 浓度 4.08 mg/dL 比 6.61 mg/dL 比 4.33 mg/dL）。第 1 组的 MPV 明显高于第 3 组（10.39 fL 比 9.39 fL，p < 0.01）。牙周参数与 MPV 之间存在弱但有统计学意义的相关性，以及 MPV 与 PD 和 CAL 之间的相关性（MPV-PD：r = 0.45，p < 0.05；MPV-CAL：r = 0.42，p < 0.05）。
CAD 患者的慢性牙周炎会导致 MPV 升高，这可能表明血小板活性增加。这种观察结果可能表明慢性牙周炎与急性冠状动脉综合征风险增加之间存在潜在的病理生理联系。
