Wyman J B, Dent J, Heddle R, Dodds W J, Toouli J, Downton J
GI Unit, Royal Adelaide Hospital, South Australia.
Gut. 1990 Jun;31(6):639-46. doi: 10.1136/gut.31.6.639.
The mechanism that controls venting of gas from the stomach into the oesophagus was studied manometrically in 14 healthy subjects. The stomach was distended abruptly with one litre of carbon dioxide. Gas reflux was characterised by an abrupt increase in basal oesophageal body pressure to intragastric pressure. Reflux of gas from the stomach into the oesophagus occurred during transient lower oesophageal sphincter relaxations that generally had a pattern distinctly different from swallow-induced lower oesophageal sphincter relaxation. Thus, at the onset of an episode of gas reflux lower oesophageal sphincter pressure had relaxed to 3 mmHg, or less, in 96% of instances. After gas loading of the stomach the prevalence of gas reflux was significantly less when the subjects were supine (1.2/10 min) than when they were sitting (6.8/10 min) (p less than 0.001). The lower oesophageal sphincter relaxations associated with most episodes of gas reflux had a distinctive pattern that resembled those of the lower oesophageal sphincter relaxations associated with acid gastro-oesophageal reflux.
对14名健康受试者进行了测压研究，以探究控制气体从胃排入食管的机制。用1升二氧化碳突然使胃扩张。气体反流的特征是食管体部基础压力突然升高至胃内压。气体从胃反流至食管发生在短暂的食管下括约肌松弛期间，其模式通常与吞咽引起的食管下括约肌松弛明显不同。因此，在气体反流发作开始时，96%的情况下食管下括约肌压力已降至3 mmHg或更低。胃充气后，受试者仰卧时（1.2次/10分钟）气体反流的发生率明显低于坐着时（6.8次/10分钟）（p<0.001）。与大多数气体反流发作相关的食管下括约肌松弛具有独特的模式，类似于与酸性胃食管反流相关的食管下括约肌松弛。
