Deshpande S R, Satyanarayana K, Rao M N A, Pai K V
Department of Medicinal and Pharmaceutical Chemistry, HSK College of Pharmacy, Bagalkote-587 101, India.
Indian J Pharm Sci. 2012 Nov;74(6):487-97. doi: 10.4103/0250-474X.110572.
Nitric oxide, a unique messenger in biological system, is ubiquitously present virtually in all tissues revealing its versatile nature of being involved in diverse physiological functions such as vascular tone, inhibition of platelet aggregation, cell adhesion, neurotransmission and enzyme and immune regulation. The tremendous advancements made in the past few decades in this area suggests that the nitric oxide modulation either by its exogenous release through nitric oxide donors or inhibition of its synthesis by nitric oxide synthase inhibitors in physiological milieu may provide newer clinical strategies for the treatment of some diseases. In this review, an attempt is made to document and understand the biological chemistry of different classes of nitric oxide modulators that would prove to be a fruitful area in the years to come.
一氧化氮是生物系统中一种独特的信使分子，几乎普遍存在于所有组织中，这揭示了其参与多种生理功能的多功能性质，如血管张力调节、抑制血小板聚集、细胞黏附、神经传递以及酶和免疫调节。过去几十年在该领域取得的巨大进展表明，在生理环境中，通过一氧化氮供体实现其外源性释放或通过一氧化氮合酶抑制剂抑制其合成来调节一氧化氮，可能为某些疾病的治疗提供新的临床策略。在这篇综述中，我们试图记录并理解不同种类一氧化氮调节剂的生物化学性质，这在未来几年将被证明是一个富有成果的领域。
