Department of Psychiatry, Yeungnam University College of Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.
Psychiatry Investig. 2013 Jun;10(2):200-2. doi: 10.4306/pi.2013.10.2.200. Epub 2013 May 30.
Sexual dysfunction is a common side effect in patients treated with antipsychotics but significant differences exist across different compounds. We report hypersexuality symptoms in two female patients with schizophrenia who were receiving treatment with aripiprazole. The patients experienced more frequent sexual desire and greater sexual preoccupation after taking aripiprazole. We discuss the potential neuro-chemical mechanisms for this and argue that aripiprazole's unique pharmacological profile, partial agonism with high affinity at dopamine D2-receptor, may have contributed to the development of these symptoms.
性功能障碍是抗精神病药物治疗患者的常见副作用，但不同药物之间存在显著差异。我们报告了两名接受阿立哌唑治疗的精神分裂症女性患者出现性欲亢进症状。这两名患者在服用阿立哌唑后性欲更加频繁，性冲动更强烈。我们讨论了这种现象的潜在神经化学机制，并认为阿立哌唑独特的药理学特性，即对多巴胺 D2 受体具有高亲和力的部分激动作用，可能导致了这些症状的发生。
