Khan Abdul Wadood, Kotta Sabna, Rana Sudha, Ansari Shahid Husain, Sharma Rakesh Kumar, Ali Javed
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Int J Pharm Investig. 2013 Jan;3(1):54-9. doi: 10.4103/2230-973X.108964.
Increased use of the radioactive materials in the field of research, medical, nuclear power plant, and industry has increased the risk of accidental exposure. Intentional use of the radioisotopes by terrorist organizations could cause exposure/contamination of a number of the population. In view of the accidental contamination, there is a need to develop self-usable decontamination formulations that could be used immediately after contamination is suspected.
Present work was planned to optimize and develop self-usable radiation decontamination cream formulation. Various pharmaceutical parameters were characterized. (99m)Tc-sodium pertechnetate was used as radiocontaminant. Static counts were recorded before and after decontamination using single photon emission computed tomography.
Decontamination efficacy of the cream was found to be 42% ± 3% at 0-0.5 h after the exposure. Primary skin irritancy test was satisfactory as no erythema or edema was observed visually after 2 weeks of the formulation application.
The decontamination studies proved the potential of EDTA to remove the radiological contaminants effectively.
研究、医疗、核电站及工业领域对放射性材料的使用增加，导致意外暴露风险上升。恐怖组织故意使用放射性同位素可能致使大量人群受到暴露/污染。鉴于意外污染情况，有必要研发可在怀疑受到污染后立即自行使用的去污配方。
本研究旨在优化并开发可自行使用的辐射去污乳膏配方。对各种药学参数进行了表征。使用高锝酸钠（99mTc）作为放射性污染物。在去污前后使用单光子发射计算机断层扫描记录静态计数。
暴露后0至0.5小时，乳膏的去污效果为42%±3%。初次皮肤刺激性试验结果令人满意，在涂抹配方2周后肉眼未观察到红斑或水肿。
去污研究证明了乙二胺四乙酸（EDTA）有效去除放射性污染物的潜力。
