Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine Chapel Hill, NC, USA.
J Gastrointestin Liver Dis. 2013 Jun;22(2):205-8.
Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition believed to have an allergic component, but the timing of the initial allergen triggers that cause the disease is poorly understood. While the clinical presentation of EoE is often of longstanding symptoms, in animal models, acute exposure to an allergen challenge successfully produces EoE. In this report, we present three cases of individuals who developed esophageal eosinophilia and EoE shortly after a clearly identified exposure to aeroallergens. These cases highlight the allergic etiology of EoE, and provide a link from humans to the previously described experimental mechanisms.
嗜酸粒细胞性食管炎（EoE）是一种慢性免疫介导的疾病，被认为具有过敏成分，但目前对于导致这种疾病的最初过敏原触发因素的时间尚不清楚。虽然 EoE 的临床表现通常是长期存在的症状，但在动物模型中，急性暴露于过敏原挑战会成功引发 EoE。在本报告中，我们介绍了三例个体在明确接触气传过敏原后不久发展为食管嗜酸性粒细胞增多和 EoE 的病例。这些病例强调了 EoE 的过敏病因，并为以前描述的实验机制提供了从人类到动物的联系。
