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肠内喂养患者的腹泻:是饮食的错?

Diarrhea in enterally fed patients: blame the diet?

机构信息

Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.

出版信息

Curr Opin Clin Nutr Metab Care. 2013 Sep;16(5):588-94. doi: 10.1097/MCO.0b013e328363bcaf.

DOI:10.1097/MCO.0b013e328363bcaf
PMID:23799327
Abstract

PURPOSE OF REVIEW

Diarrhea has great impact on enteral nutrition. The purpose of this review is to identify the factors leading to diarrhea during enteral nutrition and to provide the published updates on diarrhea prevention through nutritional intervention.

RECENT FINDINGS

Diarrhea in enteral fed patients is attributed to multiple factors, including medications (major contributor), infections, bacterial contamination, underlying disease, and enteral feeding. Diet management can alleviate diarrhea in enteral feeding. High content of fermentable oligosaccharides, disaccharides, and monosaccharides and polyols (FODMAPs) in enteral formula is postulated to induce diarrhea and lower FODMAPs formula may reduce the likelihood of diarrhea in enterally fed patients. Fiber-enriched formula can reduce the incidence of diarrhea and produce short-chain fatty acids for colonocytes. Ingesting prebiotics, nonviable probiotics or probiotic derivatives, and human lactoferrin may provide alternatives for reducing/preventing diarrhea.

SUMMARY

Enteral feeding is not generally considered the primary cause of diarrhea, which is frequently linked to prescribed medications. When diarrhea is apparent, healthcare members should evaluate the possible risk factors and systematically attempt to eliminate the underlying causes of diarrhea before reducing or suspending enteral feeding. Lower FODMAPs formula, prebiotics, probiotic derivatives, and lactoferrin may be used to manage enteral feeding-related diarrhea.

摘要

目的综述

腹泻对肠内营养有很大影响。本文旨在确定导致肠内营养相关性腹泻的因素,并提供关于通过营养干预预防腹泻的最新信息。

最近的发现

肠内喂养患者的腹泻归因于多种因素,包括药物(主要因素)、感染、细菌污染、基础疾病和肠内喂养。饮食管理可以缓解肠内喂养相关性腹泻。肠内配方中可发酵的寡糖、双糖和单糖及多元醇(FODMAPs)含量高,推测会引起腹泻,低 FODMAPs 配方可能会降低肠内喂养患者腹泻的可能性。富含纤维的配方可减少腹泻的发生,并为结肠细胞产生短链脂肪酸。摄入益生元、非活性益生菌或益生菌衍生物和人乳铁蛋白可能为减少/预防腹泻提供替代方法。

总结

肠内喂养通常不被认为是腹泻的主要原因,腹泻常与处方药物有关。当出现腹泻时,医护人员应评估可能的风险因素,并在减少或暂停肠内喂养之前,系统地尝试消除腹泻的根本原因。低 FODMAPs 配方、益生元、益生菌衍生物和乳铁蛋白可用于治疗肠内喂养相关性腹泻。

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