Cadenhead Kristin S, Addington Jean, Cannon Tyrone D, Cornblatt Barbara A, de la Fuente-Sandoval Camilo, Mathalon Dan H, Perkins Diana O, Seidman Larry J, Tsuang Ming, Walker Elaine F, Woods Scott W, Bachman Peter, Belger Ayse, Carrión Ricardo E, Donkers Franc C L, Duncan Erica, Johannesen Jason, León-Ortiz Pablo, Light Gregory, Mondragón Alejandra, Niznikiewicz Margaret, Nunag Jason, Roach Brian J, Solís-Vivanco Rodolfo
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0810, USA.
Neuroreport. 2013 Aug 7;24(11):626-30. doi: 10.1097/WNR.0b013e3283637845.
Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; however, between-site stability has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling participants studies were carried out as a part of quality assurance procedures to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) consortium, eight normal participants traveled to each of the eight NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy participants were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between-site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites.
前脉冲抑制（PPI）和声惊吓反应的反应性是精神病理学研究中广泛使用的生物行为指标。先前的研究表明，PPI和惊吓反应性在各研究点内具有较高的稳定性；然而，不同研究点之间的稳定性尚未得到证实。在两个独立的早期精神病生物标志物研究联盟中，作为质量保证程序的一部分，开展了流动参与者研究，以评估各研究点数据的一致性。在北美前驱期纵向研究（NAPLS）联盟中，8名正常参与者前往NAPLS的8个研究点中的每个点，并在每个研究点就惊吓PPI范式接受两次测试。在筹备一项双边研究时，10名健康参与者在圣地亚哥和墨西哥城均接受了两次评估。PPI和惊吓反应参数在各研究点之间及研究点内部的组内相关均具有显著性，证实了两个联盟中各研究点惊吓测量的可靠性。在NAPLS研究中，惊吓幅度存在研究点间差异，这似乎与方法或设备无关。在规划多研究点研究时，尽早制定质量保证程序并建立研究点间的可靠性以确保各研究点数据具有可比性至关重要。
